Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects

Since the 1990s, our group has been conducting basic research on regenerative medicine using various cell types to treat several central nervous system diseases, including spinal cord injury (SCI). We have reported many positive effects of the intravenous administration of mesenchymal stem cells (MS...

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Detalles Bibliográficos
Autores principales: Hirota, Ryosuke, Sasaki, Masanori, Honmou, Osamu, Yamashita, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Spine Surgery and Related Research 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447197/
https://www.ncbi.nlm.nih.gov/pubmed/37636138
http://dx.doi.org/10.22603/ssrr.2022-0234
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author Hirota, Ryosuke
Sasaki, Masanori
Honmou, Osamu
Yamashita, Toshihiko
author_facet Hirota, Ryosuke
Sasaki, Masanori
Honmou, Osamu
Yamashita, Toshihiko
author_sort Hirota, Ryosuke
collection PubMed
description Since the 1990s, our group has been conducting basic research on regenerative medicine using various cell types to treat several central nervous system diseases, including spinal cord injury (SCI). We have reported many positive effects of the intravenous administration of mesenchymal stem cells (MSCs) derived from the bone marrow. In the current study, MSCs were administered intravenously to a rat model of severe SCI (crush injury) during the acute to subacute stages-considerable motor function recovery was observed. Furthermore, MSC transplantation in a chronic-phase SCI model improved motor function. In this review, we discuss recent updates in basic research on the intravenous infusion of MSCs and prospects for SCI research.
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spelling pubmed-104471972023-08-25 Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects Hirota, Ryosuke Sasaki, Masanori Honmou, Osamu Yamashita, Toshihiko Spine Surg Relat Res Review Article Since the 1990s, our group has been conducting basic research on regenerative medicine using various cell types to treat several central nervous system diseases, including spinal cord injury (SCI). We have reported many positive effects of the intravenous administration of mesenchymal stem cells (MSCs) derived from the bone marrow. In the current study, MSCs were administered intravenously to a rat model of severe SCI (crush injury) during the acute to subacute stages-considerable motor function recovery was observed. Furthermore, MSC transplantation in a chronic-phase SCI model improved motor function. In this review, we discuss recent updates in basic research on the intravenous infusion of MSCs and prospects for SCI research. The Japanese Society for Spine Surgery and Related Research 2023-02-13 /pmc/articles/PMC10447197/ /pubmed/37636138 http://dx.doi.org/10.22603/ssrr.2022-0234 Text en Copyright © 2023 The Japanese Society for Spine Surgery and Related Research https://creativecommons.org/licenses/by-nc-nd/4.0/Spine Surgery and Related Research is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Hirota, Ryosuke
Sasaki, Masanori
Honmou, Osamu
Yamashita, Toshihiko
Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
title Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
title_full Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
title_fullStr Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
title_full_unstemmed Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
title_short Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
title_sort mesenchymal stem cell transplantation for spinal cord injury: current status and prospects
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447197/
https://www.ncbi.nlm.nih.gov/pubmed/37636138
http://dx.doi.org/10.22603/ssrr.2022-0234
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AT yamashitatoshihiko mesenchymalstemcelltransplantationforspinalcordinjurycurrentstatusandprospects

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