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Increased stiffness of omental arteries from late pregnant women at advanced maternal age

Advanced maternal age (≥35 years) is a risk factor for poor pregnancy outcomes. Pregnancy requires extensive maternal vascular adaptations, and with age, our blood vessels become stiffer and change in structure (collagen and elastin). However, the effect of advanced maternal age on the structure of...

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Autores principales: Wooldridge, Amy L., Chan, Christy, Spaans, Floor, Quon, Anita, Steinback, Craig D., Davenport, Margie H., Davidge, Sandra T., Cooke, Christy-Lynn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447229/
https://www.ncbi.nlm.nih.gov/pubmed/37493195
http://dx.doi.org/10.1042/BSR20230819
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author Wooldridge, Amy L.
Chan, Christy
Spaans, Floor
Quon, Anita
Steinback, Craig D.
Davenport, Margie H.
Davidge, Sandra T.
Cooke, Christy-Lynn M.
author_facet Wooldridge, Amy L.
Chan, Christy
Spaans, Floor
Quon, Anita
Steinback, Craig D.
Davenport, Margie H.
Davidge, Sandra T.
Cooke, Christy-Lynn M.
author_sort Wooldridge, Amy L.
collection PubMed
description Advanced maternal age (≥35 years) is a risk factor for poor pregnancy outcomes. Pregnancy requires extensive maternal vascular adaptations, and with age, our blood vessels become stiffer and change in structure (collagen and elastin). However, the effect of advanced maternal age on the structure of human resistance arteries during pregnancy is unknown. As omental resistance arteries contribute to blood pressure regulation, assessing their structure in pregnancy may inform on the causal mechanisms underlying pregnancy complications in women of advanced maternal age. Omental fat biopsies were obtained from younger (<35 years) or advanced maternal age (≥35 years) women during caesarean delivery (n = 7–9/group). Arteries (200–300 µm) were isolated and passive mechanical properties (circumferential stress and strain) assessed with pressure myography. Collagen (Masson’s Trichrome) and elastin (Verhoff) were visualized histologically and % positively-stained area was assessed. Median maternal age was 32 years (range 25–34) for younger, and 38 years (range 35–42) for women of advanced maternal age. Circumferential strain was lower in arteries from advanced maternal age versus younger women but circumferential stress was not different. Omental artery collagen levels were similar, while elastin levels were lower with advanced maternal age versus younger pregnancies. The collagen:elastin ratio was greater in arteries from advanced maternal age versus younger women. In conclusion, omental arteries from women of advanced maternal age were less compliant with less elastin compared with arteries of younger controls, which may affect how vascular stressors are tolerated during pregnancy. Understanding how vascular aging affects pregnancy adaptations may contribute to better pregnancy outcomes.
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spelling pubmed-104472292023-08-25 Increased stiffness of omental arteries from late pregnant women at advanced maternal age Wooldridge, Amy L. Chan, Christy Spaans, Floor Quon, Anita Steinback, Craig D. Davenport, Margie H. Davidge, Sandra T. Cooke, Christy-Lynn M. Biosci Rep Cardiovascular System & Vascular Biology Advanced maternal age (≥35 years) is a risk factor for poor pregnancy outcomes. Pregnancy requires extensive maternal vascular adaptations, and with age, our blood vessels become stiffer and change in structure (collagen and elastin). However, the effect of advanced maternal age on the structure of human resistance arteries during pregnancy is unknown. As omental resistance arteries contribute to blood pressure regulation, assessing their structure in pregnancy may inform on the causal mechanisms underlying pregnancy complications in women of advanced maternal age. Omental fat biopsies were obtained from younger (<35 years) or advanced maternal age (≥35 years) women during caesarean delivery (n = 7–9/group). Arteries (200–300 µm) were isolated and passive mechanical properties (circumferential stress and strain) assessed with pressure myography. Collagen (Masson’s Trichrome) and elastin (Verhoff) were visualized histologically and % positively-stained area was assessed. Median maternal age was 32 years (range 25–34) for younger, and 38 years (range 35–42) for women of advanced maternal age. Circumferential strain was lower in arteries from advanced maternal age versus younger women but circumferential stress was not different. Omental artery collagen levels were similar, while elastin levels were lower with advanced maternal age versus younger pregnancies. The collagen:elastin ratio was greater in arteries from advanced maternal age versus younger women. In conclusion, omental arteries from women of advanced maternal age were less compliant with less elastin compared with arteries of younger controls, which may affect how vascular stressors are tolerated during pregnancy. Understanding how vascular aging affects pregnancy adaptations may contribute to better pregnancy outcomes. Portland Press Ltd. 2023-08-22 /pmc/articles/PMC10447229/ /pubmed/37493195 http://dx.doi.org/10.1042/BSR20230819 Text en © 2023 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Cardiovascular System & Vascular Biology
Wooldridge, Amy L.
Chan, Christy
Spaans, Floor
Quon, Anita
Steinback, Craig D.
Davenport, Margie H.
Davidge, Sandra T.
Cooke, Christy-Lynn M.
Increased stiffness of omental arteries from late pregnant women at advanced maternal age
title Increased stiffness of omental arteries from late pregnant women at advanced maternal age
title_full Increased stiffness of omental arteries from late pregnant women at advanced maternal age
title_fullStr Increased stiffness of omental arteries from late pregnant women at advanced maternal age
title_full_unstemmed Increased stiffness of omental arteries from late pregnant women at advanced maternal age
title_short Increased stiffness of omental arteries from late pregnant women at advanced maternal age
title_sort increased stiffness of omental arteries from late pregnant women at advanced maternal age
topic Cardiovascular System & Vascular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447229/
https://www.ncbi.nlm.nih.gov/pubmed/37493195
http://dx.doi.org/10.1042/BSR20230819
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