Clonal origin of KMT2A wild-type lineage-switch leukemia following CAR-T cell and blinatumomab therapy

Children with acute lymphoblastic leukemia (ALL) undergoing anti-CD19 therapy occasionally develop acute myeloid leukemia (AML). The clonal origin of such lineage-switch leukemias(1–4) remains unresolved. Here, we reconstructed the phylogeny of multiple leukemias in a girl who, following multiply re...

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Detalles Bibliográficos
Autores principales: Coorens, Tim H. H., Collord, Grace, Treger, Taryn D., Adams, Stuart, Mitchell, Emily, Newman, Barbara, Getz, Gad, Godfrey, Anna L., Bartram, Jack, Behjati, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447231/
https://www.ncbi.nlm.nih.gov/pubmed/37474833
http://dx.doi.org/10.1038/s43018-023-00604-0

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