Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms

Aging facilitates the expansion of hematopoietic stem cells (HSCs) carrying clonal hematopoiesis-related somatic mutations and the development of myeloid malignancies, such as myeloproliferative neoplasms (MPNs). While cooperating mutations can cause transformation, it is unclear whether distinct bo...

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Detalles Bibliográficos
Autores principales: Grockowiak, Elodie, Korn, Claudia, Rak, Justyna, Lysenko, Veronika, Hallou, Adrien, Panvini, Francesca M., Williams, Matthew, Fielding, Claire, Fang, Zijian, Khatib-Massalha, Eman, García-García, Andrés, Li, Juan, Khorshed, Reema A., González-Antón, Sara, Baxter, E. Joanna, Kusumbe, Anjali, Wilkins, Bridget S., Green, Anna, Simons, Benjamin D., Harrison, Claire N., Green, Anthony R., Lo Celso, Cristina, Theocharides, Alexandre P. A., Méndez-Ferrer, Simón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447237/
https://www.ncbi.nlm.nih.gov/pubmed/37550517
http://dx.doi.org/10.1038/s43018-023-00607-x

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