Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions

Inflammation in the central nervous system can impair the function of neuronal mitochondria and contributes to axon degeneration in the common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell-type-specific mitochondrial proteomics with in vivo biosensor imaging to dissect how...

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Detalles Bibliográficos
Autores principales: Tai, Yi-Heng, Engels, Daniel, Locatelli, Giuseppe, Emmanouilidis, Ioanna, Fecher, Caroline, Theodorou, Delphine, Müller, Stephan A., Licht-Mayer, Simon, Kreutzfeldt, Mario, Wagner, Ingrid, de Mello, Natalia Prudente, Gkotzamani, Sofia-Natsouko, Trovò, Laura, Kendirli, Arek, Aljović, Almir, Breckwoldt, Michael O., Naumann, Ronald, Bareyre, Florence M., Perocchi, Fabiana, Mahad, Don, Merkler, Doron, Lichtenthaler, Stefan F., Kerschensteiner, Martin, Misgeld, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447243/
https://www.ncbi.nlm.nih.gov/pubmed/37430025
http://dx.doi.org/10.1038/s42255-023-00838-3

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