Asparagine restriction enhances CD8(+) T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

Robust and effective T cell immune surveillance and cancer immunotherapy require proper allocation of metabolic resources to sustain energetically costly processes, including growth and cytokine production. Here, we show that asparagine (Asn) restriction on CD8(+) T cells exerted opposing effects du...

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Detalles Bibliográficos
Autores principales: Gnanaprakasam, J. N. Rashida, Kushwaha, Bhavana, Liu, Lingling, Chen, Xuyong, Kang, Siwen, Wang, Tingting, Cassel, Teresa A., Adams, Christopher M., Higashi, Richard M., Scott, David A., Xin, Gang, Li, Zihai, Yang, Jun, Lane, Andrew N., Fan, Teresa W.-M., Zhang, Ji, Wang, Ruoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447245/
https://www.ncbi.nlm.nih.gov/pubmed/37550596
http://dx.doi.org/10.1038/s42255-023-00856-1

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