The serotonin transporter sustains human brown adipose tissue thermogenesis

Activation of brown adipose tissue (BAT) in humans is a strategy to treat obesity and metabolic disease. Here we show that the serotonin transporter (SERT), encoded by SLC6A4, prevents serotonin-mediated suppression of human BAT function. RNA sequencing of human primary brown and white adipocytes sh...

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Detalles Bibliográficos
Autores principales: Suchacki, Karla J., Ramage, Lynne E., Kwok, T’ng Choong, Kelman, Alexandra, McNeill, Ben T., Rodney, Stewart, Keegan, Matthew, Gray, Calum, MacNaught, Gillian, Patel, Dilip, Fletcher, Alison M., Simpson, Joanna P., Carter, Roderick N., Semple, Robert K., Homer, Natalie Z. M., Morton, Nicholas M., van Beek, Edwin J. R., Wakelin, Sonia J., Stimson, Roland H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447248/
https://www.ncbi.nlm.nih.gov/pubmed/37537371
http://dx.doi.org/10.1038/s42255-023-00839-2

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