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A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye
OBJECTIVE: Therapeutic contact lenses, able to store drug and deliver it to the eye surface in a sustained fashion, gained interest as an effective and patient-friendly alternative to eye drops. Recent animal studies also demonstrated the presence of therapeutic drug levels in the back of the eye af...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447275/ https://www.ncbi.nlm.nih.gov/pubmed/37498499 http://dx.doi.org/10.1007/s11095-023-03560-7 |
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author | Toffoletto, Nadia Saramago, Benilde Serro, Ana Paula Chauhan, Anuj |
author_facet | Toffoletto, Nadia Saramago, Benilde Serro, Ana Paula Chauhan, Anuj |
author_sort | Toffoletto, Nadia |
collection | PubMed |
description | OBJECTIVE: Therapeutic contact lenses, able to store drug and deliver it to the eye surface in a sustained fashion, gained interest as an effective and patient-friendly alternative to eye drops. Recent animal studies also demonstrated the presence of therapeutic drug levels in the back of the eye after wearing drug-loaded contact lenses, thus opening the possibility of treating the posterior segment without need of invasive intraocular injections. The drug pathways from contact lenses to the back of the eye require further investigation. METHODS: A mechanistic mathematical model was developed to evaluate the drug concentration over time in the tears, sclera and choroid, retina, aqueous humor and vitreous humor after the application of a therapeutic contact lens. The main drug transport mechanisms of the eye and the barrier properties of the different tissues were included in the model. Validation was performed by comparison with experimental data in literature. RESULTS: The model predictions of drug concentration over time reflected the experimental data both in the anterior and posterior segment of the eye. The model can differentiate between contributions to transport from different pathways. CONCLUSIONS: The model constitutes a first step towards the possibility of predicting the ocular drug distribution and the treatment efficacy in the early stage of contact lens development, and it may help reduce both the need for in vivo tests (with ethical and economic advantages) and the gap between the lens design and clinical application. It also allows for an improved understanding of drug transport in the eye. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11095-023-03560-7. |
format | Online Article Text |
id | pubmed-10447275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-104472752023-08-25 A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye Toffoletto, Nadia Saramago, Benilde Serro, Ana Paula Chauhan, Anuj Pharm Res Original Research Article OBJECTIVE: Therapeutic contact lenses, able to store drug and deliver it to the eye surface in a sustained fashion, gained interest as an effective and patient-friendly alternative to eye drops. Recent animal studies also demonstrated the presence of therapeutic drug levels in the back of the eye after wearing drug-loaded contact lenses, thus opening the possibility of treating the posterior segment without need of invasive intraocular injections. The drug pathways from contact lenses to the back of the eye require further investigation. METHODS: A mechanistic mathematical model was developed to evaluate the drug concentration over time in the tears, sclera and choroid, retina, aqueous humor and vitreous humor after the application of a therapeutic contact lens. The main drug transport mechanisms of the eye and the barrier properties of the different tissues were included in the model. Validation was performed by comparison with experimental data in literature. RESULTS: The model predictions of drug concentration over time reflected the experimental data both in the anterior and posterior segment of the eye. The model can differentiate between contributions to transport from different pathways. CONCLUSIONS: The model constitutes a first step towards the possibility of predicting the ocular drug distribution and the treatment efficacy in the early stage of contact lens development, and it may help reduce both the need for in vivo tests (with ethical and economic advantages) and the gap between the lens design and clinical application. It also allows for an improved understanding of drug transport in the eye. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11095-023-03560-7. Springer US 2023-07-27 2023 /pmc/articles/PMC10447275/ /pubmed/37498499 http://dx.doi.org/10.1007/s11095-023-03560-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Research Article Toffoletto, Nadia Saramago, Benilde Serro, Ana Paula Chauhan, Anuj A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye |
title | A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye |
title_full | A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye |
title_fullStr | A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye |
title_full_unstemmed | A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye |
title_short | A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye |
title_sort | physiology-based mathematical model to understand drug delivery from contact lenses to the back of the eye |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447275/ https://www.ncbi.nlm.nih.gov/pubmed/37498499 http://dx.doi.org/10.1007/s11095-023-03560-7 |
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