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Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells

Recently, TNF receptor type 2 (TNFR2) signaling was found to be involved in the proliferation and activation of regulatory T cells (Tregs), a subpopulation of lymphocytes that suppress immune responses. Tregs mediate peripheral immune tolerance, and the disruption of their functions causes autoimmun...

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Detalles Bibliográficos
Autores principales:	Inoue, Masaki, Tsuji, Yuta, Ueno, Reira, Miyamoto, Daisuke, Tanaka, Keisuke, Moriyasu, Yuka, Shibata, Saya, Okuda, Mei, Ando, Daisuke, Abe, Yasuhiro, Kamada, Haruhiko, Tsunoda, Shin-ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447426/ https://www.ncbi.nlm.nih.gov/pubmed/37612373 http://dx.doi.org/10.1038/s41598-023-40925-9

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