Cargando…
Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells
Recently, TNF receptor type 2 (TNFR2) signaling was found to be involved in the proliferation and activation of regulatory T cells (Tregs), a subpopulation of lymphocytes that suppress immune responses. Tregs mediate peripheral immune tolerance, and the disruption of their functions causes autoimmun...
Autores principales: | Inoue, Masaki, Tsuji, Yuta, Ueno, Reira, Miyamoto, Daisuke, Tanaka, Keisuke, Moriyasu, Yuka, Shibata, Saya, Okuda, Mei, Ando, Daisuke, Abe, Yasuhiro, Kamada, Haruhiko, Tsunoda, Shin-ichi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447426/ https://www.ncbi.nlm.nih.gov/pubmed/37612373 http://dx.doi.org/10.1038/s41598-023-40925-9 |
Ejemplares similares
-
Creation of mouse TNFR2-selective agonistic TNF mutants using a phage display technique
por: Ando, Daisuke, et al.
Publicado: (2016) -
The effect of tumour necrosis factor-α (TNF-α) muteins on human neutrophils in vitro
por: Tchorzewski, H., et al.
Publicado: (1993) -
MuteinDB: the mutein database linking substrates, products and enzymatic reactions directly with genetic variants of enzymes
por: Braun, Andreas, et al.
Publicado: (2012) -
Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections
por: Ruiz, Andy, et al.
Publicado: (2021) -
T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα
por: Shen, Yijun, et al.
Publicado: (2017)