Cardamonin protects against iron overload induced arthritis by attenuating ROS production and NLRP3 inflammasome activation via the SIRT1/p38MAPK signaling pathway

Iron homeostasis plays an essential role in joint health, while iron overload can cause damage and death of cartilage cells. Cardamonin (CAR) is a substance found in the fruit of the chasteberry plant and has anti-inflammatory and anti-tumor activities. We first administered iron dextran (500 mg/kg)...

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Detalles Bibliográficos
Autores principales: Li, Shaocong, He, Qi, Chen, Baihao, Zeng, Jiaxu, Dou, Xiangyun, Pan, Zhaofeng, Xiao, Jiacong, Li, Miao, Wang, Fanchen, Chen, Chuyi, Lin, Yuewei, Wang, Xintian, Wang, Haibin, Chen, Jianfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447427/
https://www.ncbi.nlm.nih.gov/pubmed/37612419
http://dx.doi.org/10.1038/s41598-023-40930-y

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