Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis

Haploinsufficient mutation in arginine and glutamine-rich protein 1 (Arglu1), a newly identified pre-mRNA splicing regulator, may be linked to neural developmental disorders associated with mental retardation and epilepsy in human patients, but the underlying causes remain elusive. Here we show that...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Fenyong, Huang, Shisheng, Liu, Jiahui, Tan, Chunhua, Xu, Mengqi, Wang, Dengkui, Huang, Maoqing, Zhu, Yiyao, Huang, Xingxu, He, Shuijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447433/
https://www.ncbi.nlm.nih.gov/pubmed/37612280
http://dx.doi.org/10.1038/s41419-023-06071-w

Ejemplares similares

Ejemplares similares