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Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria

The non-filarial and non-communicable disease podoconiosis affects around 4 million people and is characterized by severe leg lymphedema accompanied with painful intermittent acute inflammatory episodes, called acute dermatolymphangioadenitis (ADLA) attacks. Risk factors have been associated with th...

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Autores principales: Neidhöfer, Claudio, Nkwetta, Derick Lekealem, Fuen, Bangsi Rose, Yenban, Njodzeka Flora, Mbiatong, Nancielle, Nchanji, Gordon Takop, Korir, Patricia, Wetzig, Nina, Sieber, Martin, Thiele, Ralf, Parcina, Marijo, Klarmann-Schulz, Ute, Hoerauf, Achim, Wanji, Samuel, Ritter, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447442/
https://www.ncbi.nlm.nih.gov/pubmed/37612446
http://dx.doi.org/10.1038/s41598-023-40765-7
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author Neidhöfer, Claudio
Nkwetta, Derick Lekealem
Fuen, Bangsi Rose
Yenban, Njodzeka Flora
Mbiatong, Nancielle
Nchanji, Gordon Takop
Korir, Patricia
Wetzig, Nina
Sieber, Martin
Thiele, Ralf
Parcina, Marijo
Klarmann-Schulz, Ute
Hoerauf, Achim
Wanji, Samuel
Ritter, Manuel
author_facet Neidhöfer, Claudio
Nkwetta, Derick Lekealem
Fuen, Bangsi Rose
Yenban, Njodzeka Flora
Mbiatong, Nancielle
Nchanji, Gordon Takop
Korir, Patricia
Wetzig, Nina
Sieber, Martin
Thiele, Ralf
Parcina, Marijo
Klarmann-Schulz, Ute
Hoerauf, Achim
Wanji, Samuel
Ritter, Manuel
author_sort Neidhöfer, Claudio
collection PubMed
description The non-filarial and non-communicable disease podoconiosis affects around 4 million people and is characterized by severe leg lymphedema accompanied with painful intermittent acute inflammatory episodes, called acute dermatolymphangioadenitis (ADLA) attacks. Risk factors have been associated with the disease but the mechanisms of pathophysiology remain uncertain. Lymphedema can lead to skin lesions, which can serve as entry points for bacteria that may cause ADLA attacks leading to progression of the lymphedema. However, the microbiome of the skin of affected legs from podoconiosis individuals remains unclear. Thus, we analysed the skin microbiome of podoconiosis legs using next generation sequencing. We revealed a positive correlation between increasing lymphedema severity and non-commensal anaerobic bacteria, especially Anaerococcus provencensis, as well as a negative correlation with the presence of Corynebacterium, a constituent of normal skin flora. Disease symptoms were generally linked to higher microbial diversity and richness, which deviated from the normal composition of the skin. These findings show an association of distinct bacterial taxa with lymphedema stages, highlighting the important role of bacteria for the pathogenesis of podoconiosis and might enable a selection of better treatment regimens to manage ADLA attacks and disease progression.
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spelling pubmed-104474422023-08-25 Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria Neidhöfer, Claudio Nkwetta, Derick Lekealem Fuen, Bangsi Rose Yenban, Njodzeka Flora Mbiatong, Nancielle Nchanji, Gordon Takop Korir, Patricia Wetzig, Nina Sieber, Martin Thiele, Ralf Parcina, Marijo Klarmann-Schulz, Ute Hoerauf, Achim Wanji, Samuel Ritter, Manuel Sci Rep Article The non-filarial and non-communicable disease podoconiosis affects around 4 million people and is characterized by severe leg lymphedema accompanied with painful intermittent acute inflammatory episodes, called acute dermatolymphangioadenitis (ADLA) attacks. Risk factors have been associated with the disease but the mechanisms of pathophysiology remain uncertain. Lymphedema can lead to skin lesions, which can serve as entry points for bacteria that may cause ADLA attacks leading to progression of the lymphedema. However, the microbiome of the skin of affected legs from podoconiosis individuals remains unclear. Thus, we analysed the skin microbiome of podoconiosis legs using next generation sequencing. We revealed a positive correlation between increasing lymphedema severity and non-commensal anaerobic bacteria, especially Anaerococcus provencensis, as well as a negative correlation with the presence of Corynebacterium, a constituent of normal skin flora. Disease symptoms were generally linked to higher microbial diversity and richness, which deviated from the normal composition of the skin. These findings show an association of distinct bacterial taxa with lymphedema stages, highlighting the important role of bacteria for the pathogenesis of podoconiosis and might enable a selection of better treatment regimens to manage ADLA attacks and disease progression. Nature Publishing Group UK 2023-08-23 /pmc/articles/PMC10447442/ /pubmed/37612446 http://dx.doi.org/10.1038/s41598-023-40765-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Neidhöfer, Claudio
Nkwetta, Derick Lekealem
Fuen, Bangsi Rose
Yenban, Njodzeka Flora
Mbiatong, Nancielle
Nchanji, Gordon Takop
Korir, Patricia
Wetzig, Nina
Sieber, Martin
Thiele, Ralf
Parcina, Marijo
Klarmann-Schulz, Ute
Hoerauf, Achim
Wanji, Samuel
Ritter, Manuel
Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria
title Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria
title_full Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria
title_fullStr Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria
title_full_unstemmed Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria
title_short Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria
title_sort tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447442/
https://www.ncbi.nlm.nih.gov/pubmed/37612446
http://dx.doi.org/10.1038/s41598-023-40765-7
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