Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)

Heat shock protein 90 (Hsp90) and its co-chaperones promote cancer, and targeting Hsp90 holds promise for cancer treatment. Most of the efforts to harness this potential have focused on targeting the Hsp90 N-terminus ATP binding site. Although newer-generation inhibitors have shown improved efficacy...

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Detalles Bibliográficos
Autores principales: Patwardhan, Chaitanya A., Kommalapati, Vamsi Krishna, Llbiyi, Taoufik, Singh, Digvijay, Alfa, Eyad, Horuzsko, Anatolij, Korkaya, Hasan, Panda, Siva, Reilly, Christopher A., Popik, Vladimir, Chadli, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447550/
https://www.ncbi.nlm.nih.gov/pubmed/37612326
http://dx.doi.org/10.1038/s41598-023-40933-9

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