TGF-β1 stimulation and VDR-dependent activation modulate calcitriol action on skeletal muscle fibroblasts and Smad signalling-associated fibrogenesis

Fibroblasts play a pivotal role in fibrogenesis after skeletal muscle injury. Excess fibrous formation can disrupt contractile functions and delay functional recovery. Although vitamin D receptor (VDR) is expressed explicitly in regenerating muscle compared with uninjured muscle, how calcitriol [1α,...

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Detalles Bibliográficos
Autores principales: Srikuea, Ratchakrit, Hirunsai, Muthita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447566/
https://www.ncbi.nlm.nih.gov/pubmed/37612333
http://dx.doi.org/10.1038/s41598-023-40978-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447566/
https://www.ncbi.nlm.nih.gov/pubmed/37612333
http://dx.doi.org/10.1038/s41598-023-40978-w

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