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Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin

Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe, although muscular toxicity occurs in about 1 in 10.000 patients. In this study, we explored the role of the endocannabinoid system (ECS) during muscle toxicity induced by simvastatin. In murine C2C12 myobla...

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Detalles Bibliográficos
Autores principales:	Kalkan, Hilal, Panza, Elisabetta, Pagano, Ester, Ercolano, Giuseppe, Moriello, Claudia, Piscitelli, Fabiana, Sztretye, Mónika, Capasso, Raffaele, Di Marzo, Vincenzo, Iannotti, Fabio Arturo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447569/ https://www.ncbi.nlm.nih.gov/pubmed/37612317 http://dx.doi.org/10.1038/s41419-023-06080-9

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