Customizably designed multibodies neutralize SARS-CoV-2 in a variant-insensitive manner

The COVID-19 pandemic evolves constantly, requiring adaptable solutions to combat emerging SARS-CoV-2 variants. To address this, we created a pentameric scaffold based on a mammalian protein, which can be customized with up to 10 protein binding modules. This molecular scaffold spans roughly 20 nm a...

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Detalles Bibliográficos
Autores principales: Abreu, Cecilia, Ortega, Claudia, Olivero-Deibe, Natalia, Carrión, Federico, Gaete-Argel, Aracelly, Valiente-Echeverría, Fernando, Soto-Rifo, Ricardo, Milan Bonotto, Rafaela, Marcello, Alessandro, Pantano, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447908/
https://www.ncbi.nlm.nih.gov/pubmed/37638023
http://dx.doi.org/10.3389/fimmu.2023.1226880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447908/
https://www.ncbi.nlm.nih.gov/pubmed/37638023
http://dx.doi.org/10.3389/fimmu.2023.1226880

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