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Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective

Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences on the central...

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Autores principales: Kobiec, Tamara, Mardaraz, Claudia, Toro-Urrego, Nicolás, Kölliker-Frers, Rodolfo, Capani, Francisco, Otero-Losada, Matilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447983/
https://www.ncbi.nlm.nih.gov/pubmed/37638319
http://dx.doi.org/10.3389/fnins.2023.1214468
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author Kobiec, Tamara
Mardaraz, Claudia
Toro-Urrego, Nicolás
Kölliker-Frers, Rodolfo
Capani, Francisco
Otero-Losada, Matilde
author_facet Kobiec, Tamara
Mardaraz, Claudia
Toro-Urrego, Nicolás
Kölliker-Frers, Rodolfo
Capani, Francisco
Otero-Losada, Matilde
author_sort Kobiec, Tamara
collection PubMed
description Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences on the central nervous system (CNS) and neurological development. MetS can last several years or be lifelong, affecting the CNS in different ways and treatments can help manage condition, though there is no known cure. The early childhood years are extremely important in neurodevelopment, which extends beyond, encompassing a lifetime. Neuroplastic changes take place all life through — childhood, adolescence, adulthood, and old age — are highly sensitive to environmental input. Environmental factors have an important role in the etiopathogenesis and treatment of MetS, so environmental enrichment (EE) stands as a promising non-invasive therapeutic approach. While the EE paradigm has been designed for animal housing, its principles can be and actually are applied in cognitive, sensory, social, and physical stimulation programs for humans. Here, we briefly review the central milestones in neurodevelopment at each life stage, along with the research studies carried out on how MetS affects neurodevelopment at each life stage and the contributions that EE models can provide to improve health over the lifespan.
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spelling pubmed-104479832023-08-25 Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective Kobiec, Tamara Mardaraz, Claudia Toro-Urrego, Nicolás Kölliker-Frers, Rodolfo Capani, Francisco Otero-Losada, Matilde Front Neurosci Neuroscience Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences on the central nervous system (CNS) and neurological development. MetS can last several years or be lifelong, affecting the CNS in different ways and treatments can help manage condition, though there is no known cure. The early childhood years are extremely important in neurodevelopment, which extends beyond, encompassing a lifetime. Neuroplastic changes take place all life through — childhood, adolescence, adulthood, and old age — are highly sensitive to environmental input. Environmental factors have an important role in the etiopathogenesis and treatment of MetS, so environmental enrichment (EE) stands as a promising non-invasive therapeutic approach. While the EE paradigm has been designed for animal housing, its principles can be and actually are applied in cognitive, sensory, social, and physical stimulation programs for humans. Here, we briefly review the central milestones in neurodevelopment at each life stage, along with the research studies carried out on how MetS affects neurodevelopment at each life stage and the contributions that EE models can provide to improve health over the lifespan. Frontiers Media S.A. 2023-08-10 /pmc/articles/PMC10447983/ /pubmed/37638319 http://dx.doi.org/10.3389/fnins.2023.1214468 Text en Copyright © 2023 Kobiec, Mardaraz, Toro-Urrego, Kölliker-Frers, Capani and Otero-Losada. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kobiec, Tamara
Mardaraz, Claudia
Toro-Urrego, Nicolás
Kölliker-Frers, Rodolfo
Capani, Francisco
Otero-Losada, Matilde
Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective
title Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective
title_full Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective
title_fullStr Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective
title_full_unstemmed Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective
title_short Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective
title_sort neuroprotection in metabolic syndrome by environmental enrichment. a lifespan perspective
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447983/
https://www.ncbi.nlm.nih.gov/pubmed/37638319
http://dx.doi.org/10.3389/fnins.2023.1214468
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