Cargando…

Identification of promising methionine aminopeptidase enzyme inhibitors: A combine study of comprehensive virtual screening and dynamics simulation study

Methionine aminopeptidase (MetAP) enzymes play a critical role in bacterial cell survival by cleaving formyl-methionine initiators at N-terminal of nascent protein, a process which is vital in proper protein folding. This makes MetAP an attractive and novel antibacterial target to unveil promising a...

Descripción completa

Detalles Bibliográficos
Autor principal:	Alabbas, Alhumaidi B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448168/ https://www.ncbi.nlm.nih.gov/pubmed/37638221 http://dx.doi.org/10.1016/j.jsps.2023.101745

Ejemplares similares

Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity
por: Joharapurkar, Amit A, et al.
Publicado: (2014)

The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis
por: Esa, Rawnaq, et al.
Publicado: (2020)

Novel and Potential Small Molecule Scaffolds as DYRK1A Inhibitors by Integrated Molecular Docking-Based Virtual Screening and Dynamics Simulation Study
por: Shahroz, Mir Mohammad, et al.
Publicado: (2022)

Analysis of the stoichiometric metal activation of methionine aminopeptidase
por: Chai, Sergio C, et al.
Publicado: (2009)

Establishment of a screening protocol for identification of aminopeptidase N inhibitors
por: Niu, Miaomiao, et al.
Publicado: (2015)

Integrativesubtractive proteomics, immunoinformatics, docking, and simulation approaches reveal candidate vaccine against Sin Nombre orthohantavirus
por: Alabbas, Alhumaidi B.
Publicado: (2022)

MapB Protein is the Essential Methionine Aminopeptidase in Mycobacterium tuberculosis
por: Vanunu, Miriam, et al.
Publicado: (2019)

Methionine aminopeptidase-2 is a pivotal regulator of vasculogenic mimicry
por: Shimizu, Shota, et al.
Publicado: (2022)

Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening
por: Sanchez, Mateo I., et al.
Publicado: (2019)

Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 therapeutics
por: Alamri, Mubarak A., et al.
Publicado: (2020)

Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes
por: Ma, Ze-Qiang, et al.
Publicado: (2007)

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening
por: Ruggeri, Chiara, et al.
Publicado: (2015)

The two authentic methionine aminopeptidase genes are differentially expressed in Bacillus subtilis
por: You, CongHui, et al.
Publicado: (2005)

Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats
por: Kass, Daniel J., et al.
Publicado: (2012)

A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors
por: Carducci, Michael A., et al.
Publicado: (2023)

Identification of PARP12 Inhibitors By Virtual Screening and Molecular Dynamics Simulations
por: Almeleebia, Tahani M., et al.
Publicado: (2022)

NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells
por: Selvakumar, Ponniah, et al.
Publicado: (2009)

A mutation in the methionine aminopeptidase gene provides phage resistance in Streptococcus thermophilus
por: Labrie, Simon J., et al.
Publicado: (2019)

Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases
por: Ekpenyong, Oscar, et al.
Publicado: (2020)

Metallo-aminopeptidase inhibitors
por: Mucha, Artur, et al.
Publicado: (2010)

P1′ Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases
por: Talma, Michał, et al.
Publicado: (2020)

Discovery of anti-MERS-CoV small covalent inhibitors through pharmacophore modeling, covalent docking and molecular dynamics simulation
por: Alamri, Mubarak A., et al.
Publicado: (2021)

Analyzing the effect of mutations in SARS-CoV2 papain-like protease from Saudi isolates on protein structure and drug-protein binding: Molecular modelling and dynamics studies
por: Alabbas, Alhumaidi B., et al.
Publicado: (2022)

Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors
por: Halder, Amit K., et al.
Publicado: (2013)

Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds
por: Wanat, Weronika, et al.
Publicado: (2019)

In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases
por: Chauhan, Ranjit, et al.
Publicado: (2018)

Identification of Potential WSB1 Inhibitors by AlphaFold Modeling, Virtual Screening, and Molecular Dynamics Simulation Studies
por: Weng, Ye, et al.
Publicado: (2022)

Aminopeptidase N inhibitors and SARS
por: Kontoyiannis, Dimitrios P, et al.
Publicado: (2003)

Identification of SUMO activating enzyme 1 inhibitors utilizing virtual screening approach
por: Kumar, Ashutosh, et al.
Publicado: (2014)

Methionine aminopeptidase 2 is a key regulator of apoptotic like cell death in Leishmania donovani
por: Kumar, Ritesh, et al.
Publicado: (2017)

Author Correction: A mutation in the methionine aminopeptidase gene provides phage resistance in Streptococcus thermophilus
por: Labrie, Simon J., et al.
Publicado: (2020)

Virtual high-throughput screening: Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2
por: Ruan, Zijing, et al.
Publicado: (2023)

Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme
por: Adon, Tenzin, et al.
Publicado: (2023)

Virtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors
por: Zong, Keli, et al.
Publicado: (2021)

Identification of novel PTPRQ phosphatase inhibitors based on the virtual screening with docking simulations
por: Park, Hwangseo, et al.
Publicado: (2013)

Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition
por: Bainbridge, John, et al.
Publicado: (2007)

In Silico Screening for Novel Leucine Aminopeptidase Inhibitors with 3,4-Dihydroisoquinoline Scaffold
por: Ziemska, Joanna, et al.
Publicado: (2020)

Modeling of human M1 aminopeptidases for in silico screening of potential Plasmodium falciparum alanine aminopeptidase (PfA-M1) specific inhibitors
por: Sahi, Shakti, et al.
Publicado: (2014)

Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations
por: Zhang, Yi, et al.
Publicado: (2020)

Identifying promising GSK3β inhibitors for cancer management: a computational pipeline combining virtual screening and molecular dynamics simulations
por: Hua, Libo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gtikfvlpv123vlrss2e78omkan