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Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1

OBJECTIVE: Alterations in lipid metabolism are associated with aging and age-related diseases. Chaperone-mediated autophagy (CMA) is a lysosome-dependent process involved in specific protein degradation. Heat shock cognate 71 kDa protein (Hsc70) recognizes cytosolic proteins with KFERQ motif and all...

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Detalles Bibliográficos
Autores principales:	Choi, You-Jin, Yun, Sung Ho, Yu, Jihyeon, Mun, Yewon, Lee, Wonseok, Park, Cheon Jun, Han, Byung Woo, Lee, Byung-Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448198/ https://www.ncbi.nlm.nih.gov/pubmed/37524243 http://dx.doi.org/10.1016/j.molmet.2023.101784

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