Modeling human brain rhabdoid tumor by inactivating tumor suppressor genes in induced pluripotent stem cells

Atypical teratoid/rhabdoid tumor (ATRT) is a rare childhood malignancy that originates in the central nervous system. Over ninety-five percent of ATRT patients have biallelic inactivation of the tumor suppressor gene SMARCB1. ATRT has no standard treatment, and a major limiting factor in therapeutic...

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Detalles Bibliográficos
Autores principales: Hua, Timothy, Xue, Yu, Sarker, Drishty B., Kiran, Sonia, Li, Yan, Sang, Qing-Xiang Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448240/
https://www.ncbi.nlm.nih.gov/pubmed/37637078
http://dx.doi.org/10.1016/j.bioactmat.2023.08.009

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