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Aldosterone-producing adenoma is associated with urolithiasis in primary aldosteronism
Primary aldosteronism (PA) is associated with urolithiasis as it causes hypercalciuria and hypocitraturia. However, the influence of different subtypes of PA on urinary stone formation remains unclear. This study aimed to evaluate the association between aldosterone-producing adenoma (APA) and the b...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bioscientifica Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448598/ https://www.ncbi.nlm.nih.gov/pubmed/37410081 http://dx.doi.org/10.1530/EC-23-0056 |
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author | Kang, Victor Jing-Wei Lee, Bo-Ching Huang, Jia-Zheng Wu, Vin-Cent Lin, Yen-Hung Chang, Chin-Chen |
author_facet | Kang, Victor Jing-Wei Lee, Bo-Ching Huang, Jia-Zheng Wu, Vin-Cent Lin, Yen-Hung Chang, Chin-Chen |
author_sort | Kang, Victor Jing-Wei |
collection | PubMed |
description | Primary aldosteronism (PA) is associated with urolithiasis as it causes hypercalciuria and hypocitraturia. However, the influence of different subtypes of PA on urinary stone formation remains unclear. This study aimed to evaluate the association between aldosterone-producing adenoma (APA) and the burden of urolithiasis in patients with PA. In the present study, we enrolled 312 patients with PA from a prospectively maintained database, of whom 179 had APA. Clinical, biochemical, and imaging data (including the presence, volume, and density of urinary stones on abdominal computed tomography) were compared between groups, with employment of propensity score matching (PSM) analysis to balance possible confounding factors. Kaplan–Meier analysis was used to estimate the acute renal colic event during follow-up. After PSM for age, sex, serum calcium, phosphate, blood urea nitrogen, creatinine, and uric acid, the APA and non-APA groups had 106 patients each. Patients with APA had higher serum intact parathyroid hormone (iPTH) (79.1 ± 45.0 vs 56.1 ± 30.3, P < 0.001) and a higher prevalence of urolithiasis (27.4% vs 12.3%, P = 0.006) than non-APA patients. During follow-up, a higher incidence of acute renal colic events was noted in the APA group than the non-APA group (P = 0.011); this association remained significant (P = 0.038) after adjustment for age and sex in Cox-regression analysis. Our data suggest that APA is associated with a heavier burden of urolithiasis and higher incidence of renal colic events compared to the non-APA subtype of PA. |
format | Online Article Text |
id | pubmed-10448598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-104485982023-08-25 Aldosterone-producing adenoma is associated with urolithiasis in primary aldosteronism Kang, Victor Jing-Wei Lee, Bo-Ching Huang, Jia-Zheng Wu, Vin-Cent Lin, Yen-Hung Chang, Chin-Chen Endocr Connect Research Primary aldosteronism (PA) is associated with urolithiasis as it causes hypercalciuria and hypocitraturia. However, the influence of different subtypes of PA on urinary stone formation remains unclear. This study aimed to evaluate the association between aldosterone-producing adenoma (APA) and the burden of urolithiasis in patients with PA. In the present study, we enrolled 312 patients with PA from a prospectively maintained database, of whom 179 had APA. Clinical, biochemical, and imaging data (including the presence, volume, and density of urinary stones on abdominal computed tomography) were compared between groups, with employment of propensity score matching (PSM) analysis to balance possible confounding factors. Kaplan–Meier analysis was used to estimate the acute renal colic event during follow-up. After PSM for age, sex, serum calcium, phosphate, blood urea nitrogen, creatinine, and uric acid, the APA and non-APA groups had 106 patients each. Patients with APA had higher serum intact parathyroid hormone (iPTH) (79.1 ± 45.0 vs 56.1 ± 30.3, P < 0.001) and a higher prevalence of urolithiasis (27.4% vs 12.3%, P = 0.006) than non-APA patients. During follow-up, a higher incidence of acute renal colic events was noted in the APA group than the non-APA group (P = 0.011); this association remained significant (P = 0.038) after adjustment for age and sex in Cox-regression analysis. Our data suggest that APA is associated with a heavier burden of urolithiasis and higher incidence of renal colic events compared to the non-APA subtype of PA. Bioscientifica Ltd 2023-07-06 /pmc/articles/PMC10448598/ /pubmed/37410081 http://dx.doi.org/10.1530/EC-23-0056 Text en © the author(s) https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Kang, Victor Jing-Wei Lee, Bo-Ching Huang, Jia-Zheng Wu, Vin-Cent Lin, Yen-Hung Chang, Chin-Chen Aldosterone-producing adenoma is associated with urolithiasis in primary aldosteronism |
title | Aldosterone-producing adenoma is associated with urolithiasis in primary aldosteronism |
title_full | Aldosterone-producing adenoma is associated with urolithiasis in primary aldosteronism |
title_fullStr | Aldosterone-producing adenoma is associated with urolithiasis in primary aldosteronism |
title_full_unstemmed | Aldosterone-producing adenoma is associated with urolithiasis in primary aldosteronism |
title_short | Aldosterone-producing adenoma is associated with urolithiasis in primary aldosteronism |
title_sort | aldosterone-producing adenoma is associated with urolithiasis in primary aldosteronism |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448598/ https://www.ncbi.nlm.nih.gov/pubmed/37410081 http://dx.doi.org/10.1530/EC-23-0056 |
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