Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis

Atherosclerotic plaques form in the inner layer of arteries triggering heart attacks and strokes. Although T cells have been detected in atherosclerosis, tolerance dysfunction as a disease driver remains unexplored. Here we examine tolerance checkpoints in atherosclerotic plaques, artery tertiary ly...

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Detalles Bibliográficos
Autores principales: Wang, Zhihua, Zhang, Xi, Lu, Shu, Zhang, Chuankai, Ma, Zhe, Su, Rui, Li, Yuanfang, Sun, Ting, Li, Yutao, Hong, Mingyang, Deng, Xinyi, Monjezi, Mohammad Rafiee, Hristov, Michael, Steffens, Sabine, Santovito, Donato, Dornmair, Klaus, Ley, Klaus, Weber, Christian, Mohanta, Sarajo K., Habenicht, Andreas J. R., Yin, Changjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448629/
https://www.ncbi.nlm.nih.gov/pubmed/37621765
http://dx.doi.org/10.1038/s44161-023-00218-w

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