Pharmacophore-Based Machine Learning Model To Predict Ligand Selectivity for E3 Ligase Binders

[Image: see text] E3 ligases are enzymes that play a critical role in ubiquitin-mediated protein degradation and are involved in various cellular processes. Pharmacophore analysis is a useful approach for predicting E3 ligase binding selectivity, which involves identifying key chemical features nece...

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Detalles Bibliográficos
Autores principales: Karki, Reagon, Gadiya, Yojana, Gribbon, Philip, Zaliani, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448689/
https://www.ncbi.nlm.nih.gov/pubmed/37636935
http://dx.doi.org/10.1021/acsomega.3c02803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448689/
https://www.ncbi.nlm.nih.gov/pubmed/37636935
http://dx.doi.org/10.1021/acsomega.3c02803

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