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Pharmacophore-Based Machine Learning Model To Predict Ligand Selectivity for E3 Ligase Binders
[Image: see text] E3 ligases are enzymes that play a critical role in ubiquitin-mediated protein degradation and are involved in various cellular processes. Pharmacophore analysis is a useful approach for predicting E3 ligase binding selectivity, which involves identifying key chemical features nece...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448689/ https://www.ncbi.nlm.nih.gov/pubmed/37636935 http://dx.doi.org/10.1021/acsomega.3c02803 |