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Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls

OBJECTIVES: The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls. MATERIALS & METHODS: Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were...

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Autores principales: TAHERY, Noorollah, REZAEI TAVIRANI, Mostafa, ZAMANIAN AZODI, Mona, HAMDIEH, Mostafa, ROSTAMI NEJAD, Mohammad, MAHMOODI, Nahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448848/
https://www.ncbi.nlm.nih.gov/pubmed/37637790
http://dx.doi.org/10.22037/ijcn.v17i1.34795
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author TAHERY, Noorollah
REZAEI TAVIRANI, Mostafa
ZAMANIAN AZODI, Mona
HAMDIEH, Mostafa
ROSTAMI NEJAD, Mohammad
MAHMOODI, Nahid
author_facet TAHERY, Noorollah
REZAEI TAVIRANI, Mostafa
ZAMANIAN AZODI, Mona
HAMDIEH, Mostafa
ROSTAMI NEJAD, Mohammad
MAHMOODI, Nahid
author_sort TAHERY, Noorollah
collection PubMed
description OBJECTIVES: The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls. MATERIALS & METHODS: Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were subjected to 2DE-based proteomics accompanied with MALDI-TOF-TOF mass spectrometry. Further evaluation of the identified protein spots with the significance of p<0.05 and fold≥1.5 was done by applying protein interaction mapping via Cytoscape v. 5.3.1 and its plugins. RESULTS: The results indicate that vitamin D binding protein (GC) and haptoglobin spots (HP) significantly changed expression in OCD and OCD/BP with different expression patterns. These identified spots may contribute to OCD/BP and act as differentially recognized biomarkers comparing pure OCD and OCD/BP. CONCLUSION: The Findings imply that these proteins in the serum of the patients could be potential distinguishable biomarkers in clinical usage after related validation experiments. Therefore, this study provides a preliminary evaluation to understand OCD/BP proteome behavior better.
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spelling pubmed-104488482023-10-01 Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls TAHERY, Noorollah REZAEI TAVIRANI, Mostafa ZAMANIAN AZODI, Mona HAMDIEH, Mostafa ROSTAMI NEJAD, Mohammad MAHMOODI, Nahid Iran J Child Neurol Original Article OBJECTIVES: The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls. MATERIALS & METHODS: Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were subjected to 2DE-based proteomics accompanied with MALDI-TOF-TOF mass spectrometry. Further evaluation of the identified protein spots with the significance of p<0.05 and fold≥1.5 was done by applying protein interaction mapping via Cytoscape v. 5.3.1 and its plugins. RESULTS: The results indicate that vitamin D binding protein (GC) and haptoglobin spots (HP) significantly changed expression in OCD and OCD/BP with different expression patterns. These identified spots may contribute to OCD/BP and act as differentially recognized biomarkers comparing pure OCD and OCD/BP. CONCLUSION: The Findings imply that these proteins in the serum of the patients could be potential distinguishable biomarkers in clinical usage after related validation experiments. Therefore, this study provides a preliminary evaluation to understand OCD/BP proteome behavior better. Shahid Beheshti University of Medical Sciences 2023 2023-07-01 /pmc/articles/PMC10448848/ /pubmed/37637790 http://dx.doi.org/10.22037/ijcn.v17i1.34795 Text en © 2023 The Authors. https://creativecommons.org/licenses/by-nc/4.0/This work is published as an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
TAHERY, Noorollah
REZAEI TAVIRANI, Mostafa
ZAMANIAN AZODI, Mona
HAMDIEH, Mostafa
ROSTAMI NEJAD, Mohammad
MAHMOODI, Nahid
Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls
title Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls
title_full Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls
title_fullStr Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls
title_full_unstemmed Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls
title_short Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls
title_sort evaluating serum proteome in women with obsessive-compulsive disorder/bipolar disorder compared to pure obsessive- compulsive disorder subjects and healthy controls
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448848/
https://www.ncbi.nlm.nih.gov/pubmed/37637790
http://dx.doi.org/10.22037/ijcn.v17i1.34795
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