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Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran
Background: Thalassemia is an inherited disease with anemia and hemolysis. Blood transfusion is a routine treatment for thalassemia patients; alloimmunization is one of the complications of blood transfusion, which is very serious for these patients, especially girls and young women. Materials and M...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448921/ https://www.ncbi.nlm.nih.gov/pubmed/37638288 http://dx.doi.org/10.18502/ijhoscr.v17i1.11707 |
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author | Mollahoseini Foomani, Farzad Sadeghian, Mohammad Hadi Bagheri, Saeede Badiee, Zahra Bazargani, Reihane Aryanpour, Zahra Hallajiayan, Saeid Shams, Seyyede Fatemeh |
author_facet | Mollahoseini Foomani, Farzad Sadeghian, Mohammad Hadi Bagheri, Saeede Badiee, Zahra Bazargani, Reihane Aryanpour, Zahra Hallajiayan, Saeid Shams, Seyyede Fatemeh |
author_sort | Mollahoseini Foomani, Farzad |
collection | PubMed |
description | Background: Thalassemia is an inherited disease with anemia and hemolysis. Blood transfusion is a routine treatment for thalassemia patients; alloimmunization is one of the complications of blood transfusion, which is very serious for these patients, especially girls and young women. Materials and Methods: In this cross-sectional study, 446 thalassemia patients were examined. Demographic information of patients was extracted and recorded. The phenotype of ABO, Rh, and Kell antigens (tube method) with antisera from IMMUNDIANOSTICA Company (Germany) and the frequency of alloantibodies were determined. Results: 55.8% of the studied individuals were male, and 44.2% were female. Mean age of the studied patients was 19.94±10.63. The alloantibodies were detected in 7.5% of cell-pack receivers. The most prevalent phenotype of the ABO system was the O blood group (37.4%), and the most abundant antigen of the Rh group was ‘e’, which was found in 99.8% of the studied population. The most common alloantibody detected was Anti K (38.2%); concerning kell phenotype, (K(_)k(+)) and (K(+)k(+)) were found in 99.3% and 0.7% of patients, respectively. The frequency of Anti-D, Anti-C, Anti-c, and Anti-E was 23.5%, 14.7%, 2.9%, and 14.7%, respectively. Conclusion: According to the results of this paper, finding the compatible packed cells in terms of Kell and Rh systems antigens in addition to the ABO blood group is recommended to decrease the rate of alloantibodies in thalassemia patients. |
format | Online Article Text |
id | pubmed-10448921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-104489212023-08-25 Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran Mollahoseini Foomani, Farzad Sadeghian, Mohammad Hadi Bagheri, Saeede Badiee, Zahra Bazargani, Reihane Aryanpour, Zahra Hallajiayan, Saeid Shams, Seyyede Fatemeh Int J Hematol Oncol Stem Cell Res Original Article Background: Thalassemia is an inherited disease with anemia and hemolysis. Blood transfusion is a routine treatment for thalassemia patients; alloimmunization is one of the complications of blood transfusion, which is very serious for these patients, especially girls and young women. Materials and Methods: In this cross-sectional study, 446 thalassemia patients were examined. Demographic information of patients was extracted and recorded. The phenotype of ABO, Rh, and Kell antigens (tube method) with antisera from IMMUNDIANOSTICA Company (Germany) and the frequency of alloantibodies were determined. Results: 55.8% of the studied individuals were male, and 44.2% were female. Mean age of the studied patients was 19.94±10.63. The alloantibodies were detected in 7.5% of cell-pack receivers. The most prevalent phenotype of the ABO system was the O blood group (37.4%), and the most abundant antigen of the Rh group was ‘e’, which was found in 99.8% of the studied population. The most common alloantibody detected was Anti K (38.2%); concerning kell phenotype, (K(_)k(+)) and (K(+)k(+)) were found in 99.3% and 0.7% of patients, respectively. The frequency of Anti-D, Anti-C, Anti-c, and Anti-E was 23.5%, 14.7%, 2.9%, and 14.7%, respectively. Conclusion: According to the results of this paper, finding the compatible packed cells in terms of Kell and Rh systems antigens in addition to the ABO blood group is recommended to decrease the rate of alloantibodies in thalassemia patients. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2023-01-01 /pmc/articles/PMC10448921/ /pubmed/37638288 http://dx.doi.org/10.18502/ijhoscr.v17i1.11707 Text en Copyright © 2023 Tehran University of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Original Article Mollahoseini Foomani, Farzad Sadeghian, Mohammad Hadi Bagheri, Saeede Badiee, Zahra Bazargani, Reihane Aryanpour, Zahra Hallajiayan, Saeid Shams, Seyyede Fatemeh Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran |
title | Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran |
title_full | Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran |
title_fullStr | Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran |
title_full_unstemmed | Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran |
title_short | Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran |
title_sort | frequency of kell and rh alloantibodies in iranian thalassemia patients in khorasan razavi province, iran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448921/ https://www.ncbi.nlm.nih.gov/pubmed/37638288 http://dx.doi.org/10.18502/ijhoscr.v17i1.11707 |
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