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More than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease
Periorbital swelling is a clinical presentation with a broad differential and potentially deleterious consequence. Causes range from benign, including allergic reaction, to vision- and life-threatening, including orbital cellulitis and orbital infarction. The recent climate of SARS-CoV-2 has further...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448924/ https://www.ncbi.nlm.nih.gov/pubmed/37638285 http://dx.doi.org/10.18502/ijhoscr.v17i1.11714 |
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author | Hicks, Rachel Elizabeth Alsabri, Mohammed Peichev, Mario Kusum, Viswanathan |
author_facet | Hicks, Rachel Elizabeth Alsabri, Mohammed Peichev, Mario Kusum, Viswanathan |
author_sort | Hicks, Rachel Elizabeth |
collection | PubMed |
description | Periorbital swelling is a clinical presentation with a broad differential and potentially deleterious consequence. Causes range from benign, including allergic reaction, to vision- and life-threatening, including orbital cellulitis and orbital infarction. The recent climate of SARS-CoV-2 has further complicated this differential, as the virus poses broad clinical presentations with new manifestations reported frequently. Rapid identification of the underlying etiology is crucial, as treatment approaches diverge greatly. Here, we report the case of an African American adolescent male with a history of homozygous sickle cell anemia presenting to an inner city hospital with bilateral periorbital swelling amid the coronavirus pandemic. Differentials, including orbital cellulitis, COVID-MIS-C, orbital inflammatory syndrome, Hoagland sign, and orbital infarction secondary to sickle cell crisis are contrasted. We contrast our case with 12 case reports of orbital infarction in the setting of sickle cell crisis within the past 10 years, highlighting how these presentations, along with commonly reported findings of orbital infarction, compare with our patient. |
format | Online Article Text |
id | pubmed-10448924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-104489242023-08-25 More than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease Hicks, Rachel Elizabeth Alsabri, Mohammed Peichev, Mario Kusum, Viswanathan Int J Hematol Oncol Stem Cell Res Case Report Periorbital swelling is a clinical presentation with a broad differential and potentially deleterious consequence. Causes range from benign, including allergic reaction, to vision- and life-threatening, including orbital cellulitis and orbital infarction. The recent climate of SARS-CoV-2 has further complicated this differential, as the virus poses broad clinical presentations with new manifestations reported frequently. Rapid identification of the underlying etiology is crucial, as treatment approaches diverge greatly. Here, we report the case of an African American adolescent male with a history of homozygous sickle cell anemia presenting to an inner city hospital with bilateral periorbital swelling amid the coronavirus pandemic. Differentials, including orbital cellulitis, COVID-MIS-C, orbital inflammatory syndrome, Hoagland sign, and orbital infarction secondary to sickle cell crisis are contrasted. We contrast our case with 12 case reports of orbital infarction in the setting of sickle cell crisis within the past 10 years, highlighting how these presentations, along with commonly reported findings of orbital infarction, compare with our patient. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2023-01-01 /pmc/articles/PMC10448924/ /pubmed/37638285 http://dx.doi.org/10.18502/ijhoscr.v17i1.11714 Text en Copyright © 2023 Tehran University of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Case Report Hicks, Rachel Elizabeth Alsabri, Mohammed Peichev, Mario Kusum, Viswanathan More than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease |
title | More than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease |
title_full | More than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease |
title_fullStr | More than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease |
title_full_unstemmed | More than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease |
title_short | More than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease |
title_sort | more than meets the eye: orbital swelling in an adolescent with sickle cell disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448924/ https://www.ncbi.nlm.nih.gov/pubmed/37638285 http://dx.doi.org/10.18502/ijhoscr.v17i1.11714 |
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