Cargando…

Ensifentrine, a Novel Phosphodiesterase 3 and 4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease: Randomized, Double-Blind, Placebo-controlled, Multicenter Phase III Trials (the ENHANCE Trials)

RATIONALE: Ensifentrine is a novel, selective, dual phosphodiesterase (PDE)3 and PDE4 inhibitor with bronchodilator and antiinflammatory effects. Replicate phase III trials of nebulized ensifentrine were conducted (ENHANCE-1 and ENHANCE-2) to assess these effects in patients with chronic obstructive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anzueto, Antonio, Barjaktarevic, Igor Z., Siler, Thomas M., Rheault, Tara, Bengtsson, Thomas, Rickard, Kathleen, Sciurba, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Thoracic Society 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449067/ https://www.ncbi.nlm.nih.gov/pubmed/37364283 http://dx.doi.org/10.1164/rccm.202306-0944OC

Ejemplares similares

Symptom Improvement Following Treatment with the Inhaled Dual Phosphodiesterase 3 and 4 Inhibitor Ensifentrine in Patients with Moderate to Severe COPD – A Detailed Analysis
por: Watz, Henrik, et al.
Publicado: (2020)

Ensifentrine as a Novel, Inhaled Treatment for Patients with COPD
por: Donohue, James F, et al.
Publicado: (2023)

A Dose-Ranging Study of the Novel Inhaled Dual PDE 3 and 4 Inhibitor Ensifentrine in Patients with COPD Receiving Maintenance Tiotropium Therapy
por: Ferguson, Gary T, et al.
Publicado: (2021)

A dose-ranging study of the inhaled dual phosphodiesterase 3 and 4 inhibitor ensifentrine in COPD
por: Singh, Dave, et al.
Publicado: (2020)

A New Treatment for Chronic Obstructive Pulmonary Disease: Ensifentrine Moves Closer
por: Singh, Dave
Publicado: (2023)

Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial
por: Feil, Katharina, et al.
Publicado: (2017)

Prolonged release melatonin for improving sleep in totally blind subjects: a pilot placebo-controlled multicenter trial
por: Roth, Thomas, et al.
Publicado: (2015)

A randomized, double-blind, multicenter, placebo-controlled phase III trial to evaluate the efficacy and safety of pregabalin in Japanese patients with fibromyalgia
por: Ohta, Hiroyoshi, et al.
Publicado: (2012)

Effects of Omeprazole on Sleep Disturbance: Randomized Multicenter Double-Blind Placebo-Controlled Trial
por: Aimi, Masahito, et al.
Publicado: (2014)

Phosphodiesterase-5 Inhibitors for Premature Ejaculation: Systematic Review and Meta-Analysis of Placebo-Controlled Trials
por: Zhang, Xuebao, et al.
Publicado: (2020)

Analgesic Efficacy of Intravenous Ibuprofen in the Treatment of Postoperative Acute Pain: A Phase III Multicenter Randomized Placebo-ControlledDouble-Blind Clinical Trial
por: Zhou, Hong-Su, et al.
Publicado: (2023)

Randomized, Double-Blind, Placebo-Controlled, Global Phase III Trial of Talimogene Laherparepvec Combined With Pembrolizumab for Advanced Melanoma
por: Chesney, Jason A., et al.
Publicado: (2023)

Protocol for a multicenter, double-blind, randomized, placebo-controlled phase III trial of the inhaled β2-adrenergic receptor agonist salbutamol for transient tachypnea of the newborn (the REFSAL trial)
por: Madajczak, Dariusz, et al.
Publicado: (2023)

Cerebrolysin and Recovery After Stroke (CARS): A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial
por: Muresanu, Dafin F., et al.
Publicado: (2016)

Effects of Golden Plaster on Knee Osteoarthritis: A Multicenter Randomized, Double-Blind, Placebo-Controlled Trial
por: Chen, Yan, et al.
Publicado: (2022)

Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Pravastatin Added to First-Line Standard Chemotherapy in Small-Cell Lung Cancer (LUNGSTAR)
por: Seckl, Michael J., et al.
Publicado: (2017)

A randomized, double-blind, placebo-controlled phase III trial of duloxetine in Japanese fibromyalgia patients
por: Murakami, Masato, et al.
Publicado: (2015)

A randomised placebo-controlled double-blind multicentre trial comparing antibiotic therapy with placebo in the treatment of uncomplicated acute appendicitis: APPAC III trial study protocol
por: Sippola, Suvi, et al.
Publicado: (2018)

Fluvastatin in the first-line therapy of acute coronary syndrome: results of the multicenter, randomized, double-blind, placebo-controlled trial (the FACS-trial)
por: Ostadal, Petr, et al.
Publicado: (2010)

Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial
por: Tanaka, Atsushi, et al.
Publicado: (2017)

The German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial
por: Meyding-Lamadé, U., et al.
Publicado: (2019)

A Multicenter, Double-Blind, Randomized, Placebo-Controlled Phase 2b Trial of Cytisinicline in Adult Smokers (The ORCA-1 Trial)
por: Nides, Mitchell, et al.
Publicado: (2021)

Efficacy and Safety of Yokukansan in Treatment-Resistant Schizophrenia: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial
por: Miyaoka, Tsuyoshi, et al.
Publicado: (2015)

A Multicenter, Randomized, Double-blind, Placebo-controlled Trial of Saccharomyces boulardii in Infants and Children With Acute Diarrhea
por: Mourey, Florian, et al.
Publicado: (2020)

Trimebutine Maleate Monotherapy for Functional Dyspepsia: A Multicenter, Randomized, Double-Blind Placebo Controlled Prospective Trial
por: Kountouras, Jannis, et al.
Publicado: (2020)

Favipiravir in the Treatment of Outpatient COVID-19: A Multicenter, Randomized, Triple-Blind, Placebo-Controlled Clinical Trial
por: Vaezi, Atefeh, et al.
Publicado: (2023)

Cannabis-Based Medicine for Neuropathic Pain and Spasticity—A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial
por: Hansen, Julie Schjødtz, et al.
Publicado: (2023)

Difamilast, a selective phosphodiesterase 4 inhibitor, ointment in paediatric patients with atopic dermatitis: a phase III randomized double‐blind, vehicle‐controlled trial
por: Saeki, H., et al.
Publicado: (2021)

A Randomized Double-Blind Placebo-Controlled Phase III Trial of Selegiline Monotherapy for Early Parkinson Disease
por: Mizuno, Yoshikuni, et al.
Publicado: (2017)

Custodiol - N versus Custodiol: a prospective randomized double blind multicenter phase III Trial
por: Szabó, Gábor, et al.
Publicado: (2015)

Icenticaftor, a CFTR Potentiator, in COPD: A Multicenter, Parallel-Group, Double-Blind Clinical Trial
por: Martinez, Fernando J., et al.
Publicado: (2023)

Safety and Efficacy of the ACE-Inhibitor Ramipril in Alport Syndrome: The Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase III EARLY PRO-TECT Alport Trial in Pediatric Patients
por: Gross, Oliver, et al.
Publicado: (2012)

P1596: EFFICACY AND SAFETY OF QL0911 IN ADULT PATIENTS WITH CHRONIC PRIMARY IMMUNE THROMBOCYTOPENIA: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE III TRIAL
por: Zhou, Hu, et al.
Publicado: (2023)

Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial
por: Xu, Rui-Hua, et al.
Publicado: (2017)

Phase III, randomized, double-blind, placebo-controlled, multicenter study of lipegfilgrastim in patients with non-small cell lung cancer receiving myelosuppressive therapy
por: Volovat, Constantin, et al.
Publicado: (2015)

Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence
por: Donoghue, Kim, et al.
Publicado: (2020)

Chinese Medicine Shensongyangxin Is Effective for Patients with Bradycardia: Results of a Randomized, Double-Blind, Placebo-Controlled Multicenter Trial
por: Liu, Yunfang, et al.
Publicado: (2014)

Intravenous Ibuprofen for Treatment of Post-Operative Pain: A Multicenter, Double Blind, Placebo-Controlled, Randomized Clinical Trial
por: Gago Martínez, Andrea, et al.
Publicado: (2016)

Efficacy and Safety of “URSA Complex” in Subjects with Physical Fatigue: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial
por: Kim, Kwang-Min, et al.
Publicado: (2016)

NGM282 for Treatment of Patients With Primary Biliary Cholangitis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Trial
por: Mayo, Marlyn J., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ggaualvn6elad8gepsuitm7mpg