Cargando…
Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy
Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449145/ https://www.ncbi.nlm.nih.gov/pubmed/37616317 http://dx.doi.org/10.1371/journal.pone.0290609 |
_version_ | 1785094884446699520 |
---|---|
author | Yatani, Atsuhiko Katsurada, Naoko Fukui, Takafumi Yamada, Jun Satoh, Hiroki Mimura, Chihiro Hazama, Daisuke Yamamoto, Masatsugu Jimbo, Naoe Tanaka, Tomonori Tachihara, Motoko |
author_facet | Yatani, Atsuhiko Katsurada, Naoko Fukui, Takafumi Yamada, Jun Satoh, Hiroki Mimura, Chihiro Hazama, Daisuke Yamamoto, Masatsugu Jimbo, Naoe Tanaka, Tomonori Tachihara, Motoko |
author_sort | Yatani, Atsuhiko |
collection | PubMed |
description | Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope. |
format | Online Article Text |
id | pubmed-10449145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-104491452023-08-25 Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy Yatani, Atsuhiko Katsurada, Naoko Fukui, Takafumi Yamada, Jun Satoh, Hiroki Mimura, Chihiro Hazama, Daisuke Yamamoto, Masatsugu Jimbo, Naoe Tanaka, Tomonori Tachihara, Motoko PLoS One Research Article Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope. Public Library of Science 2023-08-24 /pmc/articles/PMC10449145/ /pubmed/37616317 http://dx.doi.org/10.1371/journal.pone.0290609 Text en © 2023 Yatani et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yatani, Atsuhiko Katsurada, Naoko Fukui, Takafumi Yamada, Jun Satoh, Hiroki Mimura, Chihiro Hazama, Daisuke Yamamoto, Masatsugu Jimbo, Naoe Tanaka, Tomonori Tachihara, Motoko Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy |
title | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy |
title_full | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy |
title_fullStr | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy |
title_full_unstemmed | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy |
title_short | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy |
title_sort | diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: a comparison with thin bronchoscopy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449145/ https://www.ncbi.nlm.nih.gov/pubmed/37616317 http://dx.doi.org/10.1371/journal.pone.0290609 |
work_keys_str_mv | AT yataniatsuhiko diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT katsuradanaoko diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT fukuitakafumi diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT yamadajun diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT satohhiroki diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT mimurachihiro diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT hazamadaisuke diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT yamamotomasatsugu diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT jimbonaoe diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT tanakatomonori diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT tachiharamotoko diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy |