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Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy

Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are...

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Autores principales: Yatani, Atsuhiko, Katsurada, Naoko, Fukui, Takafumi, Yamada, Jun, Satoh, Hiroki, Mimura, Chihiro, Hazama, Daisuke, Yamamoto, Masatsugu, Jimbo, Naoe, Tanaka, Tomonori, Tachihara, Motoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449145/
https://www.ncbi.nlm.nih.gov/pubmed/37616317
http://dx.doi.org/10.1371/journal.pone.0290609
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author Yatani, Atsuhiko
Katsurada, Naoko
Fukui, Takafumi
Yamada, Jun
Satoh, Hiroki
Mimura, Chihiro
Hazama, Daisuke
Yamamoto, Masatsugu
Jimbo, Naoe
Tanaka, Tomonori
Tachihara, Motoko
author_facet Yatani, Atsuhiko
Katsurada, Naoko
Fukui, Takafumi
Yamada, Jun
Satoh, Hiroki
Mimura, Chihiro
Hazama, Daisuke
Yamamoto, Masatsugu
Jimbo, Naoe
Tanaka, Tomonori
Tachihara, Motoko
author_sort Yatani, Atsuhiko
collection PubMed
description Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope.
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spelling pubmed-104491452023-08-25 Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy Yatani, Atsuhiko Katsurada, Naoko Fukui, Takafumi Yamada, Jun Satoh, Hiroki Mimura, Chihiro Hazama, Daisuke Yamamoto, Masatsugu Jimbo, Naoe Tanaka, Tomonori Tachihara, Motoko PLoS One Research Article Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope. Public Library of Science 2023-08-24 /pmc/articles/PMC10449145/ /pubmed/37616317 http://dx.doi.org/10.1371/journal.pone.0290609 Text en © 2023 Yatani et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yatani, Atsuhiko
Katsurada, Naoko
Fukui, Takafumi
Yamada, Jun
Satoh, Hiroki
Mimura, Chihiro
Hazama, Daisuke
Yamamoto, Masatsugu
Jimbo, Naoe
Tanaka, Tomonori
Tachihara, Motoko
Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy
title Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy
title_full Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy
title_fullStr Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy
title_full_unstemmed Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy
title_short Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy
title_sort diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: a comparison with thin bronchoscopy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449145/
https://www.ncbi.nlm.nih.gov/pubmed/37616317
http://dx.doi.org/10.1371/journal.pone.0290609
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