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Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians
BACKGROUND: Ethnicity impacts cardiovascular disease (CVD) risk, and South Asians demonstrate a higher risk than White Europeans. Arterial stiffness is known to contribute to CVD, and differences in arterial stiffness between ethnicities could explain the disparity in CVD risk. We compared central a...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449187/ https://www.ncbi.nlm.nih.gov/pubmed/37616275 http://dx.doi.org/10.1371/journal.pone.0290118 |
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author | van der Sluijs, Koen M. Thannhauser, Jos Visser, Iris M. Nabeel, P. M. Raj, Kiran V. Malik, Afrah E. F. Reesink, Koen D. Eijsvogels, Thijs M. H. Bakker, Esmée A. Kaur, Prabhdeep Joseph, Jayaraj Thijssen, Dick H. J. |
author_facet | van der Sluijs, Koen M. Thannhauser, Jos Visser, Iris M. Nabeel, P. M. Raj, Kiran V. Malik, Afrah E. F. Reesink, Koen D. Eijsvogels, Thijs M. H. Bakker, Esmée A. Kaur, Prabhdeep Joseph, Jayaraj Thijssen, Dick H. J. |
author_sort | van der Sluijs, Koen M. |
collection | PubMed |
description | BACKGROUND: Ethnicity impacts cardiovascular disease (CVD) risk, and South Asians demonstrate a higher risk than White Europeans. Arterial stiffness is known to contribute to CVD, and differences in arterial stiffness between ethnicities could explain the disparity in CVD risk. We compared central and local arterial stiffness between White Europeans and South Asians and investigated which factors are associated with arterial stiffness. METHODS: Data were collected from cohorts of White Europeans (the Netherlands) and South Asians (India). We matched cohorts on individual level using age, sex, and body mass index (BMI). Arterial stiffness was measured with ARTSENS® Plus. Central stiffness was expressed as carotid-femoral pulse wave velocity (cf-PWV, m/s), and local carotid stiffness was quantified using the carotid stiffness index (Beta) and pressure-strain elastic modulus (Epsilon, kPa). We compared arterial stiffness between cohorts and used multivariable linear regression to identify factors related to stiffness. RESULTS: We included n = 121 participants per cohort (age 53±10 years, 55% male, BMI 24 kg/m(2)). Cf-PWV was lower in White Europeans compared to South Asians (6.8±1.9 vs. 8.2±1.8 m/s, p<0.001), but no differences were found for local stiffness parameters Beta (5.4±2.4 vs. 5.8±2.3, p = 0.17) and Epsilon (72±35 vs. 70±31 kPa, p = 0.56). Age (standardized β, 95% confidence interval: 0.28, 0.17–0.39), systolic blood pressure (0.32, 0.21–0.43), and South Asian ethnicity (0.46, 0.35–0.57) were associated with cf-PWV; associations were similar between cohorts (p>0.05 for interaction). Systolic blood pressure was associated with carotid stiffness in both cohorts, whereas age was associated to carotid stiffness only in South Asians and BMI only in White Europeans. CONCLUSION: Ethnicity is associated with central but not local arterial stiffness. Conversely, ethnicity seems to modify associations between CVD risk factors and local but not central arterial stiffness. This suggests that ethnicity interacts with arterial stiffness measures and the association of these measures with CVD risk factors. |
format | Online Article Text |
id | pubmed-10449187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-104491872023-08-25 Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians van der Sluijs, Koen M. Thannhauser, Jos Visser, Iris M. Nabeel, P. M. Raj, Kiran V. Malik, Afrah E. F. Reesink, Koen D. Eijsvogels, Thijs M. H. Bakker, Esmée A. Kaur, Prabhdeep Joseph, Jayaraj Thijssen, Dick H. J. PLoS One Research Article BACKGROUND: Ethnicity impacts cardiovascular disease (CVD) risk, and South Asians demonstrate a higher risk than White Europeans. Arterial stiffness is known to contribute to CVD, and differences in arterial stiffness between ethnicities could explain the disparity in CVD risk. We compared central and local arterial stiffness between White Europeans and South Asians and investigated which factors are associated with arterial stiffness. METHODS: Data were collected from cohorts of White Europeans (the Netherlands) and South Asians (India). We matched cohorts on individual level using age, sex, and body mass index (BMI). Arterial stiffness was measured with ARTSENS® Plus. Central stiffness was expressed as carotid-femoral pulse wave velocity (cf-PWV, m/s), and local carotid stiffness was quantified using the carotid stiffness index (Beta) and pressure-strain elastic modulus (Epsilon, kPa). We compared arterial stiffness between cohorts and used multivariable linear regression to identify factors related to stiffness. RESULTS: We included n = 121 participants per cohort (age 53±10 years, 55% male, BMI 24 kg/m(2)). Cf-PWV was lower in White Europeans compared to South Asians (6.8±1.9 vs. 8.2±1.8 m/s, p<0.001), but no differences were found for local stiffness parameters Beta (5.4±2.4 vs. 5.8±2.3, p = 0.17) and Epsilon (72±35 vs. 70±31 kPa, p = 0.56). Age (standardized β, 95% confidence interval: 0.28, 0.17–0.39), systolic blood pressure (0.32, 0.21–0.43), and South Asian ethnicity (0.46, 0.35–0.57) were associated with cf-PWV; associations were similar between cohorts (p>0.05 for interaction). Systolic blood pressure was associated with carotid stiffness in both cohorts, whereas age was associated to carotid stiffness only in South Asians and BMI only in White Europeans. CONCLUSION: Ethnicity is associated with central but not local arterial stiffness. Conversely, ethnicity seems to modify associations between CVD risk factors and local but not central arterial stiffness. This suggests that ethnicity interacts with arterial stiffness measures and the association of these measures with CVD risk factors. Public Library of Science 2023-08-24 /pmc/articles/PMC10449187/ /pubmed/37616275 http://dx.doi.org/10.1371/journal.pone.0290118 Text en © 2023 van der Sluijs et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article van der Sluijs, Koen M. Thannhauser, Jos Visser, Iris M. Nabeel, P. M. Raj, Kiran V. Malik, Afrah E. F. Reesink, Koen D. Eijsvogels, Thijs M. H. Bakker, Esmée A. Kaur, Prabhdeep Joseph, Jayaraj Thijssen, Dick H. J. Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians |
title | Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians |
title_full | Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians |
title_fullStr | Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians |
title_full_unstemmed | Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians |
title_short | Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians |
title_sort | central and local arterial stiffness in white europeans compared to age-, sex-, and bmi-matched south asians |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449187/ https://www.ncbi.nlm.nih.gov/pubmed/37616275 http://dx.doi.org/10.1371/journal.pone.0290118 |
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