Cargando…
Regulation of coronavirus nsp15 cleavage specificity by RNA structure
SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, has had an enduring impact on global public health. However, SARS-CoV-2 is only one of multiple pathogenic human coronaviruses (CoVs) to have emerged since the turn of the century. CoVs encode for several nonstructural proteins (nsps) that ar...
Autores principales: | Salukhe, Indraneel, Choi, Ryan, Van Voorhis, Wesley, Barrett, Lynn, Hyde, Jennifer |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449227/ https://www.ncbi.nlm.nih.gov/pubmed/37616296 http://dx.doi.org/10.1371/journal.pone.0290675 |
Ejemplares similares
-
High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity
por: Choi, Ryan, et al.
Publicado: (2021) -
SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage
por: Huang, Cheng, et al.
Publicado: (2011) -
Kinetic analysis of RNA cleavage by coronavirus Nsp15 endonuclease: Evidence for acid–base catalysis and substrate-dependent metal ion activation
por: Huang, Tong, et al.
Publicado: (2023) -
Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
por: Scott, Benjamin M., et al.
Publicado: (2022) -
Exploring cleavage activity of NSP15 using single molecule PIE-FRET
por: Gordon, Kenya, et al.
Publicado: (2023)