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Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment

N6-methyladenosine (m6A) is the most abundant RNA modification in eukaryotes, and it participates in the regulation of pathophysiological processes in various diseases, including malignant tumors, by regulating the expression and function of both coding and non-coding RNAs (ncRNAs). More and more st...

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Autores principales: Zhang, YanJun, Zhan, Lijuan, Li, Jing, Jiang, Xue, Yin, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449301/
https://www.ncbi.nlm.nih.gov/pubmed/37178254
http://dx.doi.org/10.18632/aging.204679
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author Zhang, YanJun
Zhan, Lijuan
Li, Jing
Jiang, Xue
Yin, Li
author_facet Zhang, YanJun
Zhan, Lijuan
Li, Jing
Jiang, Xue
Yin, Li
author_sort Zhang, YanJun
collection PubMed
description N6-methyladenosine (m6A) is the most abundant RNA modification in eukaryotes, and it participates in the regulation of pathophysiological processes in various diseases, including malignant tumors, by regulating the expression and function of both coding and non-coding RNAs (ncRNAs). More and more studies demonstrated that m6A modification regulates the production, stability, and degradation of ncRNAs and that ncRNAs also regulate the expression of m6A-related proteins. Tumor microenvironment (TME) refers to the internal and external environment of tumor cells, which is composed of numerous tumor stromal cells, immune cells, immune factors, and inflammatory factors that are closely related to tumors occurrence and development. Recent studies have suggested that crosstalk between m6A modifications and ncRNAs plays an important role in the biological regulation of TME. In this review, we summarized and analyzed the effects of m6A modification-associated ncRNAs on TME from various perspectives, including tumor proliferation, angiogenesis, invasion and metastasis, and immune escape. Herein, we showed that m6A-related ncRNAs can not only be expected to become detection markers of tumor tissue samples, but can also be wrapped into exosomes and secreted into body fluids, thus exhibiting potential as markers for liquid biopsy. This review provides a deeper understanding of the relationship between m6A-related ncRNAs and TME, which is of great significance to the development of a new strategy for precise tumor therapy.
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spelling pubmed-104493012023-08-25 Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment Zhang, YanJun Zhan, Lijuan Li, Jing Jiang, Xue Yin, Li Aging (Albany NY) Review N6-methyladenosine (m6A) is the most abundant RNA modification in eukaryotes, and it participates in the regulation of pathophysiological processes in various diseases, including malignant tumors, by regulating the expression and function of both coding and non-coding RNAs (ncRNAs). More and more studies demonstrated that m6A modification regulates the production, stability, and degradation of ncRNAs and that ncRNAs also regulate the expression of m6A-related proteins. Tumor microenvironment (TME) refers to the internal and external environment of tumor cells, which is composed of numerous tumor stromal cells, immune cells, immune factors, and inflammatory factors that are closely related to tumors occurrence and development. Recent studies have suggested that crosstalk between m6A modifications and ncRNAs plays an important role in the biological regulation of TME. In this review, we summarized and analyzed the effects of m6A modification-associated ncRNAs on TME from various perspectives, including tumor proliferation, angiogenesis, invasion and metastasis, and immune escape. Herein, we showed that m6A-related ncRNAs can not only be expected to become detection markers of tumor tissue samples, but can also be wrapped into exosomes and secreted into body fluids, thus exhibiting potential as markers for liquid biopsy. This review provides a deeper understanding of the relationship between m6A-related ncRNAs and TME, which is of great significance to the development of a new strategy for precise tumor therapy. Impact Journals 2023-05-12 /pmc/articles/PMC10449301/ /pubmed/37178254 http://dx.doi.org/10.18632/aging.204679 Text en Copyright: © 2023 Zhang et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Zhang, YanJun
Zhan, Lijuan
Li, Jing
Jiang, Xue
Yin, Li
Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment
title Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment
title_full Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment
title_fullStr Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment
title_full_unstemmed Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment
title_short Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment
title_sort insights into n6-methyladenosine (m6a) modification of noncoding rna in tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449301/
https://www.ncbi.nlm.nih.gov/pubmed/37178254
http://dx.doi.org/10.18632/aging.204679
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