Oncogenic Ras and ΔNp63α cooperate to recruit immunosuppressive polymorphonuclear myeloid-derived suppressor cells in a mouse model of squamous cancer pathogenesis

INTRODUCTION: Amplification of human chromosome 3q26-29, which encodes oncoprotein ΔNp63 among other isoforms of the p63 family, is a feature common to squamous cell carcinomas (SCCs) of multiple tissue origins. Along with overexpression of ΔNp63, activation of the protooncogene, RAS, whether by ove...

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Detalles Bibliográficos
Autores principales: Sakakibara, Nozomi, Clavijo, Paúl E., Sievers, Cem, Gray, Veronica C., King, Kathryn E., George, Andrea L., Ponnamperuma, Roshini M., Walter, Beatriz A., Chen, Zhong, Van Waes, Carter, Allen, Clint T., Weinberg, Wendy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449460/
https://www.ncbi.nlm.nih.gov/pubmed/37638000
http://dx.doi.org/10.3389/fimmu.2023.1200970

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