MIR31HG, a potential lncRNA in human cancers and non-cancers

Long non-coding RNAs have recently attracted considerable attention due to their aberrant expression in human diseases. LncMIR31HG is a novel lncRNA that is abnormally expressed in multiple diseases and implicated in various stages of disease progression. A large proportion of recent studies have in...

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Autores principales: Ruan, Luxi, Lei, Jing, Yuan, Yihang, Li, Huizi, Yang, Hui, Wang, Jinyan, Zhang, Quanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449471/
https://www.ncbi.nlm.nih.gov/pubmed/37636269
http://dx.doi.org/10.3389/fgene.2023.1145454
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author Ruan, Luxi
Lei, Jing
Yuan, Yihang
Li, Huizi
Yang, Hui
Wang, Jinyan
Zhang, Quanan
author_facet Ruan, Luxi
Lei, Jing
Yuan, Yihang
Li, Huizi
Yang, Hui
Wang, Jinyan
Zhang, Quanan
author_sort Ruan, Luxi
collection PubMed
description Long non-coding RNAs have recently attracted considerable attention due to their aberrant expression in human diseases. LncMIR31HG is a novel lncRNA that is abnormally expressed in multiple diseases and implicated in various stages of disease progression. A large proportion of recent studies have indicated that MIR31HG has biological functions by triggering various signalling pathways in the pathogenesis of human diseases, especially cancers. More importantly, the abnormal expression of MIR31HG makes it a potential biomarker in diagnosis and prognosis, as well as a promising target for treatments. This review aims to systematically summarize the gene polymorphism, expression profiles, biological roles, underlying mechanisms, and clinical applications of MIR31HG in human diseases.
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spelling pubmed-104494712023-08-25 MIR31HG, a potential lncRNA in human cancers and non-cancers Ruan, Luxi Lei, Jing Yuan, Yihang Li, Huizi Yang, Hui Wang, Jinyan Zhang, Quanan Front Genet Genetics Long non-coding RNAs have recently attracted considerable attention due to their aberrant expression in human diseases. LncMIR31HG is a novel lncRNA that is abnormally expressed in multiple diseases and implicated in various stages of disease progression. A large proportion of recent studies have indicated that MIR31HG has biological functions by triggering various signalling pathways in the pathogenesis of human diseases, especially cancers. More importantly, the abnormal expression of MIR31HG makes it a potential biomarker in diagnosis and prognosis, as well as a promising target for treatments. This review aims to systematically summarize the gene polymorphism, expression profiles, biological roles, underlying mechanisms, and clinical applications of MIR31HG in human diseases. Frontiers Media S.A. 2023-08-10 /pmc/articles/PMC10449471/ /pubmed/37636269 http://dx.doi.org/10.3389/fgene.2023.1145454 Text en Copyright © 2023 Ruan, Lei, Yuan, Li, Yang, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Ruan, Luxi
Lei, Jing
Yuan, Yihang
Li, Huizi
Yang, Hui
Wang, Jinyan
Zhang, Quanan
MIR31HG, a potential lncRNA in human cancers and non-cancers
title MIR31HG, a potential lncRNA in human cancers and non-cancers
title_full MIR31HG, a potential lncRNA in human cancers and non-cancers
title_fullStr MIR31HG, a potential lncRNA in human cancers and non-cancers
title_full_unstemmed MIR31HG, a potential lncRNA in human cancers and non-cancers
title_short MIR31HG, a potential lncRNA in human cancers and non-cancers
title_sort mir31hg, a potential lncrna in human cancers and non-cancers
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449471/
https://www.ncbi.nlm.nih.gov/pubmed/37636269
http://dx.doi.org/10.3389/fgene.2023.1145454
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