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Host genetic backgrounds: the key to determining parasite-host adaptation

Parasitic diseases pose a significant threat to global public health, particularly in developing countries. Host genetic factors play a crucial role in determining susceptibility and resistance to infection. Recent advances in molecular and biological technologies have enabled significant breakthrou...

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Autores principales: Ye, Caixia, Zhang, Lianhua, Tang, Lili, Duan, Yongjun, Liu, Ji, Zhou, Hongli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449477/
https://www.ncbi.nlm.nih.gov/pubmed/37637465
http://dx.doi.org/10.3389/fcimb.2023.1228206
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author Ye, Caixia
Zhang, Lianhua
Tang, Lili
Duan, Yongjun
Liu, Ji
Zhou, Hongli
author_facet Ye, Caixia
Zhang, Lianhua
Tang, Lili
Duan, Yongjun
Liu, Ji
Zhou, Hongli
author_sort Ye, Caixia
collection PubMed
description Parasitic diseases pose a significant threat to global public health, particularly in developing countries. Host genetic factors play a crucial role in determining susceptibility and resistance to infection. Recent advances in molecular and biological technologies have enabled significant breakthroughs in understanding the impact of host genes on parasite adaptation. In this comprehensive review, we analyze the host genetic factors that influence parasite adaptation, including hormones, nitric oxide, immune cells, cytokine gene polymorphisms, parasite-specific receptors, and metabolites. We also establish an interactive network to better illustrate the complex relationship between host genetic factors and parasite-host adaptation. Additionally, we discuss future directions and collaborative research priorities in the parasite-host adaptation field, including investigating the impact of host genes on the microbiome, developing more sophisticated models, identifying and characterizing parasite-specific receptors, utilizing patient-derived sera as diagnostic and therapeutic tools, and developing novel treatments and management strategies targeting specific host genetic factors. This review highlights the need for a comprehensive and systematic approach to investigating the underlying mechanisms of parasite-host adaptation, which requires interdisciplinary collaborations among biologists, geneticists, immunologists, and clinicians. By deepening our understanding of the complex interactions between host genetics and parasite adaptation, we can develop more effective and targeted interventions to prevent and treat parasitic diseases. Overall, this review provides a valuable resource for researchers and clinicians working in the parasitology field and offers insights into the future directions of this critical research area.
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spelling pubmed-104494772023-08-25 Host genetic backgrounds: the key to determining parasite-host adaptation Ye, Caixia Zhang, Lianhua Tang, Lili Duan, Yongjun Liu, Ji Zhou, Hongli Front Cell Infect Microbiol Cellular and Infection Microbiology Parasitic diseases pose a significant threat to global public health, particularly in developing countries. Host genetic factors play a crucial role in determining susceptibility and resistance to infection. Recent advances in molecular and biological technologies have enabled significant breakthroughs in understanding the impact of host genes on parasite adaptation. In this comprehensive review, we analyze the host genetic factors that influence parasite adaptation, including hormones, nitric oxide, immune cells, cytokine gene polymorphisms, parasite-specific receptors, and metabolites. We also establish an interactive network to better illustrate the complex relationship between host genetic factors and parasite-host adaptation. Additionally, we discuss future directions and collaborative research priorities in the parasite-host adaptation field, including investigating the impact of host genes on the microbiome, developing more sophisticated models, identifying and characterizing parasite-specific receptors, utilizing patient-derived sera as diagnostic and therapeutic tools, and developing novel treatments and management strategies targeting specific host genetic factors. This review highlights the need for a comprehensive and systematic approach to investigating the underlying mechanisms of parasite-host adaptation, which requires interdisciplinary collaborations among biologists, geneticists, immunologists, and clinicians. By deepening our understanding of the complex interactions between host genetics and parasite adaptation, we can develop more effective and targeted interventions to prevent and treat parasitic diseases. Overall, this review provides a valuable resource for researchers and clinicians working in the parasitology field and offers insights into the future directions of this critical research area. Frontiers Media S.A. 2023-08-10 /pmc/articles/PMC10449477/ /pubmed/37637465 http://dx.doi.org/10.3389/fcimb.2023.1228206 Text en Copyright © 2023 Ye, Zhang, Tang, Duan, Liu and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Ye, Caixia
Zhang, Lianhua
Tang, Lili
Duan, Yongjun
Liu, Ji
Zhou, Hongli
Host genetic backgrounds: the key to determining parasite-host adaptation
title Host genetic backgrounds: the key to determining parasite-host adaptation
title_full Host genetic backgrounds: the key to determining parasite-host adaptation
title_fullStr Host genetic backgrounds: the key to determining parasite-host adaptation
title_full_unstemmed Host genetic backgrounds: the key to determining parasite-host adaptation
title_short Host genetic backgrounds: the key to determining parasite-host adaptation
title_sort host genetic backgrounds: the key to determining parasite-host adaptation
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449477/
https://www.ncbi.nlm.nih.gov/pubmed/37637465
http://dx.doi.org/10.3389/fcimb.2023.1228206
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