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Targeted gene deletions in the dimorphic fungal pathogen Histoplasma using an optimized episomal CRISPR/Cas9 system
The rapid development of CRISPR/CRISPR-associated (Cas) systems has revolutionized the ability to produce genetic mutations in a desired locus, particularly in organisms with low rates of homologous recombination. Histoplasma is an important respiratory and systemic fungal pathogen that has few reve...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Microbiology
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449496/ https://www.ncbi.nlm.nih.gov/pubmed/37389430 http://dx.doi.org/10.1128/msphere.00178-23 |