Cargando…

A novel Modulator of Ring Stage Translation (MRST) gene alters artemisinin sensitivity in Plasmodium falciparum

The implementation of artemisinin (ART) combination therapies (ACTs) has greatly decreased deaths caused by Plasmodium falciparum malaria, but increasing ACT resistance in Southeast Asia and Africa could reverse this progress. Parasite population genetic studies have identified numerous genes, singl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simmons, Caroline, Gibbons, Justin, Wang, Chengqi, Pires, Camilla Valente, Zhang, Min, Siddiqui, Faiza, Oberstaller, Jenna, Casandra, Debora, Seyfang, Andreas, Cui, Liwang, Otto, Thomas D., Adams, John H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449512/ https://www.ncbi.nlm.nih.gov/pubmed/37219373 http://dx.doi.org/10.1128/msphere.00152-23

Ejemplares similares

Protein KIC5 is a novel regulator of artemisinin stress response in the malaria parasite Plasmodium falciparum
por: Simmons, Caroline F., et al.
Publicado: (2023)

Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins
por: Pires, Camilla Valente, et al.
Publicado: (2023)

Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum
por: Chawla, Jyotsna, et al.
Publicado: (2023)

Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum
por: Oberstaller, Jenna, et al.
Publicado: (2021)

The Plasmodium falciparum Nuclear Protein Phosphatase NIF4 Is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity
por: Zhu, Xiaotong, et al.
Publicado: (2022)

MRST 1994
Publicado: (1994)

Role of Plasmodium falciparum Kelch 13 Protein Mutations in P. falciparum Populations from Northeastern Myanmar in Mediating Artemisinin Resistance
por: Siddiqui, Faiza Amber, et al.
Publicado: (2020)

Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook
por: Siddiqui, Faiza Amber, et al.
Publicado: (2021)

20th Annual MRST Meeting on High-Energy Physics : MRST '98
por: Moore, Guy D, et al.
Publicado: (1998)

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
por: Zhang, Min, et al.
Publicado: (2021)

Novel phenotypic resistance to artemisinin results in reduced exposure to drug at the most sensitive stage of intraerythrocytic development in Plasmodium falciparum
por: Hott, Amanda, et al.
Publicado: (2014)

Update of MRST Parton Distributions
por: Thorne, R.S., et al.
Publicado: (2002)

19th MRST Meeting
por: Collective
Publicado: (1997)

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
por: Xie, Stanley C., et al.
Publicado: (2016)

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage
por: Kümpornsin, Krittikorn, et al.
Publicado: (2021)

Ring-stage growth arrest: Metabolic basis of artemisinin tolerance in Plasmodium falciparum
por: Yu, Xinyu, et al.
Publicado: (2022)

Plasmodium falciparum: multifaceted resistance to artemisinins
por: Paloque, Lucie, et al.
Publicado: (2016)

In vitro susceptibility of Plasmodium falciparum isolates from the China-Myanmar border area to artemisinins and correlation with K13 mutations
por: Zhang, Jie, et al.
Publicado: (2019)

Interactions between tafenoquine and artemisinin-combination therapy partner drug in asexual and sexual stage Plasmodium falciparum
por: Kemirembe, Karen, et al.
Publicado: (2017)

Artemisinin exposure at the ring or trophozoite stage impacts Plasmodium falciparum sexual conversion differently
por: Portugaliza, Harvie P, et al.
Publicado: (2020)

Targeting Gametocytes of the Malaria Parasite Plasmodium falciparum in a Functional Genomics Era: Next Steps
por: Chawla, Jyotsna, et al.
Publicado: (2021)

Laboratory Detection of Artemisinin-Resistant Plasmodium falciparum
por: Chotivanich, Kesinee, et al.
Publicado: (2014)

Mechanisms of artemisinin resistance in Plasmodium falciparum malaria
por: Suresh, Niraja, et al.
Publicado: (2018)

MRST 2002 : a Tribute to George Leibbrandt
por: Elias, Victor, et al.
Publicado: (2002)

Imidazolopiperazines Kill both Rings and Dormant Rings in Wild-Type and K13 Artemisinin-Resistant Plasmodium falciparum In Vitro
por: Dembele, Laurent, et al.
Publicado: (2018)

Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania
por: Mugittu, Kefas, et al.
Publicado: (2006)

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
por: Miotto, Olivo, et al.
Publicado: (2013)

Artemisinin‐naphthoquine for treating uncomplicated Plasmodium falciparum malaria
por: Isba, Rachel, et al.
Publicado: (2015)

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
por: Wang, Jigang, et al.
Publicado: (2015)

Plasmodium falciparum rosetting protects schizonts against artemisinin
por: Lee, Wenn-Chyau, et al.
Publicado: (2021)

Plasmodium falciparum resistance to artemisinin-based combination therapies
por: Ward, Kurt E, et al.
Publicado: (2022)

A type II protein arginine methyltransferase regulates merozoite invasion in Plasmodium falciparum
por: Lucky, Amuza Byaruhanga, et al.
Publicado: (2023)

MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites
por: Wang, Chengqi, et al.
Publicado: (2023)

Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses
por: Lucky, Amuza Byaruhanga, et al.
Publicado: (2023)

Phenotypic Screens Identify Parasite Genetic Factors Associated with Malarial Fever Response in Plasmodium falciparum piggyBac Mutants
por: Thomas, Phaedra, et al.
Publicado: (2016)

Fitness Loss under Amino Acid Starvation in Artemisinin-Resistant Plasmodium falciparum Isolates from Cambodia
por: Bunditvorapoom, Duangkamon, et al.
Publicado: (2018)

Alternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity
por: Kite, Whitney A., et al.
Publicado: (2016)

Ring stage dormancy of Plasmodium falciparum tolerant to artemisinin and its analogues – A genetically regulated “Sleeping Beauty”
por: Auparakkitanon, Saranya, et al.
Publicado: (2023)

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
por: Mbengue, Alassane, et al.
Publicado: (2015)

Observing in real time the evolution of artemisinin resistance in Plasmodium falciparum
por: Sibley, Carol Hopkins
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_k2t6aelh7ndn9fsbac7uepvese