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Sterile inflammation in liver transplantation
Sterile inflammation is the immune response to damage-associated molecular patterns (DAMPs) released during cell death in the absence of foreign pathogens. In the setting of solid organ transplantation, ischemia-reperfusion injury results in mitochondria-mediated production of reactive oxygen and ni...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449546/ https://www.ncbi.nlm.nih.gov/pubmed/37636574 http://dx.doi.org/10.3389/fmed.2023.1223224 |
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author | Kahan, Riley Cray, Paul L. Abraham, Nader Gao, Qimeng Hartwig, Matthew G. Pollara, Justin J. Barbas, Andrew S. |
author_facet | Kahan, Riley Cray, Paul L. Abraham, Nader Gao, Qimeng Hartwig, Matthew G. Pollara, Justin J. Barbas, Andrew S. |
author_sort | Kahan, Riley |
collection | PubMed |
description | Sterile inflammation is the immune response to damage-associated molecular patterns (DAMPs) released during cell death in the absence of foreign pathogens. In the setting of solid organ transplantation, ischemia-reperfusion injury results in mitochondria-mediated production of reactive oxygen and nitrogen species that are a major cause of uncontrolled cell death and release of various DAMPs from the graft tissue. When properly regulated, the immune response initiated by DAMP-sensing serves as means of damage control and is necessary for initiation of recovery pathways and re-establishment of homeostasis. In contrast, a dysregulated or overt sterile inflammatory response can inadvertently lead to further injury through recruitment of immune cells, innate immune cell activation, and sensitization of the adaptive immune system. In liver transplantation, sterile inflammation may manifest as early graft dysfunction, acute graft failure, or increased risk of immunosuppression-resistant rejection. Understanding the mechanisms of the development of sterile inflammation in the setting of liver transplantation is crucial for finding reliable biomarkers that predict graft function, and for development of therapeutic approaches to improve long-term transplant outcomes. Here, we discuss the recent advances that have been made to elucidate the early signs of sterile inflammation and extent of damage from it. We also discuss new therapeutics that may be effective in quelling the detrimental effects of sterile inflammation. |
format | Online Article Text |
id | pubmed-10449546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104495462023-08-25 Sterile inflammation in liver transplantation Kahan, Riley Cray, Paul L. Abraham, Nader Gao, Qimeng Hartwig, Matthew G. Pollara, Justin J. Barbas, Andrew S. Front Med (Lausanne) Medicine Sterile inflammation is the immune response to damage-associated molecular patterns (DAMPs) released during cell death in the absence of foreign pathogens. In the setting of solid organ transplantation, ischemia-reperfusion injury results in mitochondria-mediated production of reactive oxygen and nitrogen species that are a major cause of uncontrolled cell death and release of various DAMPs from the graft tissue. When properly regulated, the immune response initiated by DAMP-sensing serves as means of damage control and is necessary for initiation of recovery pathways and re-establishment of homeostasis. In contrast, a dysregulated or overt sterile inflammatory response can inadvertently lead to further injury through recruitment of immune cells, innate immune cell activation, and sensitization of the adaptive immune system. In liver transplantation, sterile inflammation may manifest as early graft dysfunction, acute graft failure, or increased risk of immunosuppression-resistant rejection. Understanding the mechanisms of the development of sterile inflammation in the setting of liver transplantation is crucial for finding reliable biomarkers that predict graft function, and for development of therapeutic approaches to improve long-term transplant outcomes. Here, we discuss the recent advances that have been made to elucidate the early signs of sterile inflammation and extent of damage from it. We also discuss new therapeutics that may be effective in quelling the detrimental effects of sterile inflammation. Frontiers Media S.A. 2023-08-10 /pmc/articles/PMC10449546/ /pubmed/37636574 http://dx.doi.org/10.3389/fmed.2023.1223224 Text en Copyright © 2023 Kahan, Cray, Abraham, Gao, Hartwig, Pollara and Barbas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Kahan, Riley Cray, Paul L. Abraham, Nader Gao, Qimeng Hartwig, Matthew G. Pollara, Justin J. Barbas, Andrew S. Sterile inflammation in liver transplantation |
title | Sterile inflammation in liver transplantation |
title_full | Sterile inflammation in liver transplantation |
title_fullStr | Sterile inflammation in liver transplantation |
title_full_unstemmed | Sterile inflammation in liver transplantation |
title_short | Sterile inflammation in liver transplantation |
title_sort | sterile inflammation in liver transplantation |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449546/ https://www.ncbi.nlm.nih.gov/pubmed/37636574 http://dx.doi.org/10.3389/fmed.2023.1223224 |
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