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Deep brain stimulation for substance use disorder: a systematic review and meta-analysis

OBJECTIVE: Substance use disorder (SUD) is a significant public health issue with a high mortality rate. Deep brain stimulation (DBS) has shown promising results in treating SUD in certain cases. In this study, we conducted a meta-analysis to evaluate the efficacy of DBS in the treatment of SUD and...

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Autores principales: Shaheen, Nour, Shaheen, Ahmed, Sarica, Can, Singh, Arun, Zanaty, Mario, Johari, Karim, Yang, Andrew, Zesiewicz, Theresa, Dalm, Brian, Bezchlibnyk, Yarema, Lozano, Andres M., Flouty, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449586/
https://www.ncbi.nlm.nih.gov/pubmed/37636824
http://dx.doi.org/10.3389/fpsyt.2023.1231760
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author Shaheen, Nour
Shaheen, Ahmed
Sarica, Can
Singh, Arun
Zanaty, Mario
Johari, Karim
Yang, Andrew
Zesiewicz, Theresa
Dalm, Brian
Bezchlibnyk, Yarema
Lozano, Andres M.
Flouty, Oliver
author_facet Shaheen, Nour
Shaheen, Ahmed
Sarica, Can
Singh, Arun
Zanaty, Mario
Johari, Karim
Yang, Andrew
Zesiewicz, Theresa
Dalm, Brian
Bezchlibnyk, Yarema
Lozano, Andres M.
Flouty, Oliver
author_sort Shaheen, Nour
collection PubMed
description OBJECTIVE: Substance use disorder (SUD) is a significant public health issue with a high mortality rate. Deep brain stimulation (DBS) has shown promising results in treating SUD in certain cases. In this study, we conducted a meta-analysis to evaluate the efficacy of DBS in the treatment of SUD and reduction of relapse rates. METHODS: We performed a thorough and methodical search of the existing scientific literature, adhering to the PRISMA guidelines, to identify 16 original studies that fulfilled our inclusion criteria. We used the evidence levels recommended by the Oxford Centre for Evidence-Based Medicine to assess bias. The R version 4.2.3 software was utilized to calculate the mean effect size. We estimated study heterogeneity by employing tau2 and I2 indices and conducting Cochran’s Q test. RESULTS: The results showed that DBS treatment resulted in a significant improvement in the clinical SUD scales of patients, with an average improvement of 59.6%. The observed relapse rate was 8%. The meta-analysis estimated a mean effect size of 55.9 [40.4; 71.4]. Heterogeneity analysis showed a large degree of heterogeneity among the included studies. Subgroup and meta-regression analysis based on age and SUD type suggested that DBS may be more effective for patients above 45 years of age, and for alcohol and opioid addiction compared to nicotine addiction. CONCLUSION: The current literature suggests that DBS has a moderate effect on SUD symptoms. However, the limited number of studies and small sample size indicate that more research is needed to better understand the factors that influence its effectiveness.
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spelling pubmed-104495862023-08-25 Deep brain stimulation for substance use disorder: a systematic review and meta-analysis Shaheen, Nour Shaheen, Ahmed Sarica, Can Singh, Arun Zanaty, Mario Johari, Karim Yang, Andrew Zesiewicz, Theresa Dalm, Brian Bezchlibnyk, Yarema Lozano, Andres M. Flouty, Oliver Front Psychiatry Psychiatry OBJECTIVE: Substance use disorder (SUD) is a significant public health issue with a high mortality rate. Deep brain stimulation (DBS) has shown promising results in treating SUD in certain cases. In this study, we conducted a meta-analysis to evaluate the efficacy of DBS in the treatment of SUD and reduction of relapse rates. METHODS: We performed a thorough and methodical search of the existing scientific literature, adhering to the PRISMA guidelines, to identify 16 original studies that fulfilled our inclusion criteria. We used the evidence levels recommended by the Oxford Centre for Evidence-Based Medicine to assess bias. The R version 4.2.3 software was utilized to calculate the mean effect size. We estimated study heterogeneity by employing tau2 and I2 indices and conducting Cochran’s Q test. RESULTS: The results showed that DBS treatment resulted in a significant improvement in the clinical SUD scales of patients, with an average improvement of 59.6%. The observed relapse rate was 8%. The meta-analysis estimated a mean effect size of 55.9 [40.4; 71.4]. Heterogeneity analysis showed a large degree of heterogeneity among the included studies. Subgroup and meta-regression analysis based on age and SUD type suggested that DBS may be more effective for patients above 45 years of age, and for alcohol and opioid addiction compared to nicotine addiction. CONCLUSION: The current literature suggests that DBS has a moderate effect on SUD symptoms. However, the limited number of studies and small sample size indicate that more research is needed to better understand the factors that influence its effectiveness. Frontiers Media S.A. 2023-08-10 /pmc/articles/PMC10449586/ /pubmed/37636824 http://dx.doi.org/10.3389/fpsyt.2023.1231760 Text en Copyright © 2023 Shaheen, Shaheen, Sarica, Singh, Zanaty, Johari, Yang, Zesiewicz, Dalm, Bezchlibnyk, Lozano and Flouty. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Shaheen, Nour
Shaheen, Ahmed
Sarica, Can
Singh, Arun
Zanaty, Mario
Johari, Karim
Yang, Andrew
Zesiewicz, Theresa
Dalm, Brian
Bezchlibnyk, Yarema
Lozano, Andres M.
Flouty, Oliver
Deep brain stimulation for substance use disorder: a systematic review and meta-analysis
title Deep brain stimulation for substance use disorder: a systematic review and meta-analysis
title_full Deep brain stimulation for substance use disorder: a systematic review and meta-analysis
title_fullStr Deep brain stimulation for substance use disorder: a systematic review and meta-analysis
title_full_unstemmed Deep brain stimulation for substance use disorder: a systematic review and meta-analysis
title_short Deep brain stimulation for substance use disorder: a systematic review and meta-analysis
title_sort deep brain stimulation for substance use disorder: a systematic review and meta-analysis
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449586/
https://www.ncbi.nlm.nih.gov/pubmed/37636824
http://dx.doi.org/10.3389/fpsyt.2023.1231760
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