Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression

BACKGROUND: Intracytoplasmic inclusions comprised of aggregated alpha-synuclein (αsyn) represent a key histopathological feature of neurological disorders collectively termed “synucleinopathies,” which includes Parkinson’s disease (PD). Mutations and multiplications in the SNCA gene encoding αsyn ca...

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Detalles Bibliográficos
Autores principales: Fagen, Sara J., Burgess, Jeremy D., Lim, Melina J., Amerna, Danilyn, Kaya, Zeynep B., Faroqi, Ayman H., Perisetla, Priyanka, DeMeo, Natasha N., Stojkovska, Iva, Quiriconi, Drew J., Mazzulli, Joseph R., Delenclos, Marion, Boschen, Suelen L., McLean, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449643/
https://www.ncbi.nlm.nih.gov/pubmed/37637959
http://dx.doi.org/10.3389/fnagi.2023.1179086

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