A Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma

BACKGROUND: The first-in-class brain-penetrating synthetic hydroxylated lipid idroxioleic acid (2-OHOA; sodium 2-hydroxyoleate), activates sphingomyelin synthase expression and regulates membrane-lipid composition and mitochondrial energy production, inducing cancer cell autophagy. We report the fin...

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Detalles Bibliográficos
Autores principales: Lopez, Juanita, Lai-Kwon, Julia, Molife, Rhoda, Welsh, Liam, Tunariu, Nina, Roda, Desamparados, Fernández-García, Paula, Lladó, Victoria, McNicholl, Adrian G., Rosselló, Catalina A., Taylor, Richard J., Azaro, Analía, Rodón, Jordi, Sludden, Julieann, Veal, Gareth J., Plummer, Ruth, Urruticoechea, Ander, Lahuerta, Ainhara, Mujika, Karmele, Escribá, Pablo V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449773/
https://www.ncbi.nlm.nih.gov/pubmed/37488446
http://dx.doi.org/10.1038/s41416-023-02356-1

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