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A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway

Human epidermal growth factor receptor 2 (HER2) is a protein that is overexpressed in some types of cancer, including breast and urothelial cancer. Here we found that HER2 was present in a portion of colon cancer patients, raising the possibility of using anti-HER2 therapy. RC48, a novel antibody-dr...

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Detalles Bibliográficos
Autores principales:	Wu, Xiaohan, Xu, Lingyan, Li, Xiaofei, Zhou, Yirui, Han, Xiao, Zhang, Wei, Wang, Weicheng, Guo, Wenjie, Liu, Wen, Xu, Qiang, Gu, Yanhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449775/ https://www.ncbi.nlm.nih.gov/pubmed/37620320 http://dx.doi.org/10.1038/s41419-023-06073-8

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