Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography

Iridocorneal angle (ICA) details particularly the trabecular meshwork (TM), Schlemm’s canal (SC), and collector channels (CCs) play crucial roles in the regulation of the aqueous outflow in the eyes and are closely associated with glaucoma. Current clinical gonioscopy imaging provides no depth infor...

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Autores principales: Luo, Shangbang, Holland, Guy, Khazaeinezhad, Reza, Bradford, Samantha, Joshi, Rohan, Juhasz, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449890/
https://www.ncbi.nlm.nih.gov/pubmed/37620338
http://dx.doi.org/10.1038/s41598-023-37248-0
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author Luo, Shangbang
Holland, Guy
Khazaeinezhad, Reza
Bradford, Samantha
Joshi, Rohan
Juhasz, Tibor
author_facet Luo, Shangbang
Holland, Guy
Khazaeinezhad, Reza
Bradford, Samantha
Joshi, Rohan
Juhasz, Tibor
author_sort Luo, Shangbang
collection PubMed
description Iridocorneal angle (ICA) details particularly the trabecular meshwork (TM), Schlemm’s canal (SC), and collector channels (CCs) play crucial roles in the regulation of the aqueous outflow in the eyes and are closely associated with glaucoma. Current clinical gonioscopy imaging provides no depth information, and studies of 3D high-resolution optical coherence tomography (OCT) imaging of these structures are limited. We developed a custom-built spectral-domain (SD-) OCT imaging system to fully characterize the angle details. Imaging of a human cadaver eye reveals the visibility of details in the TM/SC/CC region via a ’crossline’ scanning and a series of image processing. This shows that ICA imaging can be used for preoperative glaucoma inspections in the clinical setting with the proposed prototype.
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spelling pubmed-104498902023-08-26 Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography Luo, Shangbang Holland, Guy Khazaeinezhad, Reza Bradford, Samantha Joshi, Rohan Juhasz, Tibor Sci Rep Article Iridocorneal angle (ICA) details particularly the trabecular meshwork (TM), Schlemm’s canal (SC), and collector channels (CCs) play crucial roles in the regulation of the aqueous outflow in the eyes and are closely associated with glaucoma. Current clinical gonioscopy imaging provides no depth information, and studies of 3D high-resolution optical coherence tomography (OCT) imaging of these structures are limited. We developed a custom-built spectral-domain (SD-) OCT imaging system to fully characterize the angle details. Imaging of a human cadaver eye reveals the visibility of details in the TM/SC/CC region via a ’crossline’ scanning and a series of image processing. This shows that ICA imaging can be used for preoperative glaucoma inspections in the clinical setting with the proposed prototype. Nature Publishing Group UK 2023-08-24 /pmc/articles/PMC10449890/ /pubmed/37620338 http://dx.doi.org/10.1038/s41598-023-37248-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Luo, Shangbang
Holland, Guy
Khazaeinezhad, Reza
Bradford, Samantha
Joshi, Rohan
Juhasz, Tibor
Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography
title Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography
title_full Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography
title_fullStr Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography
title_full_unstemmed Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography
title_short Iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography
title_sort iridocorneal angle imaging of a human donor eye by spectral-domain optical coherence tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449890/
https://www.ncbi.nlm.nih.gov/pubmed/37620338
http://dx.doi.org/10.1038/s41598-023-37248-0
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