The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension

Human WIPI β-propellers function as PI3P effectors in autophagy, with WIPI4 and WIPI3 being able to link autophagy control by AMPK and TORC1 to the formation of autophagosomes. WIPI1, instead, assists WIPI2 in efficiently recruiting the ATG16L1 complex at the nascent autophagosome, which in turn pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Sporbeck, Katharina, Haas, Maximilian L., Pastor-Maldonado, Carmen J., Schüssele, David S., Hunter, Catherine, Takacs, Zsuzsanna, Diogo de Oliveira, Ana L., Franz-Wachtel, Mirita, Charsou, Chara, Pfisterer, Simon G., Gubas, Andrea, Haller, Patricia K., Knorr, Roland L., Kaulich, Manuel, Macek, Boris, Eskelinen, Eeva-Liisa, Simonsen, Anne, Proikas-Cezanne, Tassula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449903/
https://www.ncbi.nlm.nih.gov/pubmed/37620393
http://dx.doi.org/10.1038/s42003-023-05236-9

Ejemplares similares

Ejemplares similares