Cargando…
Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb
OBJECTIVE: To evaluate the impact of a postoperative baseline (PB) MRI on diagnostic confidence and performance in detecting local recurrence (LR) of soft-tissue sarcoma (STS) of the limb. MATERIALS AND METHODS: A total of 72 patients (8 with LR, 64 without LR) with primary STS of the limb were incl...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449988/ https://www.ncbi.nlm.nih.gov/pubmed/37129611 http://dx.doi.org/10.1007/s00256-023-04341-4 |
_version_ | 1785095091215400960 |
---|---|
author | Goller, Sophia Samira Reidler, Paul Rudolph, Jan Rückel, Johannes Hesse, Nina Schmidt, Vanessa Franziska Dürr, Hans Roland Klein, Alexander Lindner, Lars Hartwin Di Gioia, Dorit Kuhn, Isabella Ricke, Jens Erber, Bernd |
author_facet | Goller, Sophia Samira Reidler, Paul Rudolph, Jan Rückel, Johannes Hesse, Nina Schmidt, Vanessa Franziska Dürr, Hans Roland Klein, Alexander Lindner, Lars Hartwin Di Gioia, Dorit Kuhn, Isabella Ricke, Jens Erber, Bernd |
author_sort | Goller, Sophia Samira |
collection | PubMed |
description | OBJECTIVE: To evaluate the impact of a postoperative baseline (PB) MRI on diagnostic confidence and performance in detecting local recurrence (LR) of soft-tissue sarcoma (STS) of the limb. MATERIALS AND METHODS: A total of 72 patients (8 with LR, 64 without LR) with primary STS of the limb were included. Routine follow-up MRI (1.5 T) at 6 and approximately 36 months (mean(LR): 39.7 months; mean(no LR): 34.9 months) after multimodal therapy or at time of LR were assessed by three independent readers using a 5-point Likert scale. Furthermore, the following imaging parameters were evaluated: presence of a mass, signal characteristics at T2- and T1-weighted imaging, contrast enhancement (CE), and in some of the cases signal intensity on the apparent diffusion coefficient (ADC). U-test, McNemar test, and ROC-analysis were applied. Interobserver reliability was calculated using Fleiss kappa statistics. A p value of 0.05 was considered statistically significant. RESULTS: The presence of a PB MRI significantly improved diagnostic confidence in detecting LR of STS (p < 0.001) and slightly increased specificity (mean specificity without PE 74.1% and with presence of PB MRI 81.2%); however, not to a significant level. The presence of a mass showed highest diagnostic performance and highest interreader agreement (AUC [%]; κ: 73.1–83.6; 0.34) followed by T2-hyperintensity (50.8–66.7; 0.08), CE (52.4–62.5; 0.13), and T1-hypointensity (54.7–77.3; 0.23). ADC showed an AUC of 65.6–96.6% and a κ of 0.55. CONCLUSION: The presence of a PB MRI increases diagnostic confidence in detecting LR of STS of the limb. |
format | Online Article Text |
id | pubmed-10449988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-104499882023-08-26 Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb Goller, Sophia Samira Reidler, Paul Rudolph, Jan Rückel, Johannes Hesse, Nina Schmidt, Vanessa Franziska Dürr, Hans Roland Klein, Alexander Lindner, Lars Hartwin Di Gioia, Dorit Kuhn, Isabella Ricke, Jens Erber, Bernd Skeletal Radiol Scientific Article OBJECTIVE: To evaluate the impact of a postoperative baseline (PB) MRI on diagnostic confidence and performance in detecting local recurrence (LR) of soft-tissue sarcoma (STS) of the limb. MATERIALS AND METHODS: A total of 72 patients (8 with LR, 64 without LR) with primary STS of the limb were included. Routine follow-up MRI (1.5 T) at 6 and approximately 36 months (mean(LR): 39.7 months; mean(no LR): 34.9 months) after multimodal therapy or at time of LR were assessed by three independent readers using a 5-point Likert scale. Furthermore, the following imaging parameters were evaluated: presence of a mass, signal characteristics at T2- and T1-weighted imaging, contrast enhancement (CE), and in some of the cases signal intensity on the apparent diffusion coefficient (ADC). U-test, McNemar test, and ROC-analysis were applied. Interobserver reliability was calculated using Fleiss kappa statistics. A p value of 0.05 was considered statistically significant. RESULTS: The presence of a PB MRI significantly improved diagnostic confidence in detecting LR of STS (p < 0.001) and slightly increased specificity (mean specificity without PE 74.1% and with presence of PB MRI 81.2%); however, not to a significant level. The presence of a mass showed highest diagnostic performance and highest interreader agreement (AUC [%]; κ: 73.1–83.6; 0.34) followed by T2-hyperintensity (50.8–66.7; 0.08), CE (52.4–62.5; 0.13), and T1-hypointensity (54.7–77.3; 0.23). ADC showed an AUC of 65.6–96.6% and a κ of 0.55. CONCLUSION: The presence of a PB MRI increases diagnostic confidence in detecting LR of STS of the limb. Springer Berlin Heidelberg 2023-05-02 2023 /pmc/articles/PMC10449988/ /pubmed/37129611 http://dx.doi.org/10.1007/s00256-023-04341-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Scientific Article Goller, Sophia Samira Reidler, Paul Rudolph, Jan Rückel, Johannes Hesse, Nina Schmidt, Vanessa Franziska Dürr, Hans Roland Klein, Alexander Lindner, Lars Hartwin Di Gioia, Dorit Kuhn, Isabella Ricke, Jens Erber, Bernd Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb |
title | Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb |
title_full | Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb |
title_fullStr | Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb |
title_full_unstemmed | Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb |
title_short | Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb |
title_sort | impact of postoperative baseline mri on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb |
topic | Scientific Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449988/ https://www.ncbi.nlm.nih.gov/pubmed/37129611 http://dx.doi.org/10.1007/s00256-023-04341-4 |
work_keys_str_mv | AT gollersophiasamira impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT reidlerpaul impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT rudolphjan impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT ruckeljohannes impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT hessenina impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT schmidtvanessafranziska impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT durrhansroland impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT kleinalexander impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT lindnerlarshartwin impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT digioiadorit impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT kuhnisabella impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT rickejens impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb AT erberbernd impactofpostoperativebaselinemriondiagnosticconfidenceandperformanceindetectinglocalrecurrenceofsofttissuesarcomaofthelimb |