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Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review

Diabetes is a significant chronic endocrine/metabolism disorder that can result in a number of life-threatening consequences. According to research, the gut microbiota is strongly linked to the development of diabetes, making it a viable target for diabetes treatment. The intestinal microbiota affec...

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Autores principales: Su, Min, Tang, Ting, Tang, Weiwei, Long, Yu, Wang, Lin, Liu, Meiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450032/
https://www.ncbi.nlm.nih.gov/pubmed/37638043
http://dx.doi.org/10.3389/fimmu.2023.1243834
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author Su, Min
Tang, Ting
Tang, Weiwei
Long, Yu
Wang, Lin
Liu, Meiling
author_facet Su, Min
Tang, Ting
Tang, Weiwei
Long, Yu
Wang, Lin
Liu, Meiling
author_sort Su, Min
collection PubMed
description Diabetes is a significant chronic endocrine/metabolism disorder that can result in a number of life-threatening consequences. According to research, the gut microbiota is strongly linked to the development of diabetes, making it a viable target for diabetes treatment. The intestinal microbiota affects intestinal barrier function, organism immunity, and thus glucose metabolism and lipid metabolism. According to research, a disruption in the intestinal microbiota causes a decrease in short-chain fatty acids (SCFAs), alters the metabolism of bile acids (BAs), branched-chain amino acids (BCAAs), lipopolysaccharide (LPS), and endotoxin secretion, resulting in insulin resistance, chronic inflammation, and the progression to type 2 diabetes mellitus (T2DM). Astragali Radix is a medicinal herb of the same genus as food that has been extensively researched for treating diabetes mellitus with promising results in recent years. Polysaccharides, saponins, flavonoids, and other components are important. Among them, Astragaloside has a role in protecting the cellular integrity of the pancreas and liver, can leading to alleviation of insulin resistance and reducing blood glucose and triglyceride (TC) levels; The primary impact of Astragalus polysaccharides (APS) on diabetes is a decrease in insulin resistance, encouragement of islet cell proliferation, and suppression of islet β cell death; Astragali Radix flavonoids are known to enhance immunity, anti-inflammatory, regulate glucose metabolism and control the progression of diabetes. This study summarizes recent studies on Astragali Radix and its group formulations in the treatment of type 2 diabetes mellitus by modulating the intestinal microbiota.
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spelling pubmed-104500322023-08-26 Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review Su, Min Tang, Ting Tang, Weiwei Long, Yu Wang, Lin Liu, Meiling Front Immunol Immunology Diabetes is a significant chronic endocrine/metabolism disorder that can result in a number of life-threatening consequences. According to research, the gut microbiota is strongly linked to the development of diabetes, making it a viable target for diabetes treatment. The intestinal microbiota affects intestinal barrier function, organism immunity, and thus glucose metabolism and lipid metabolism. According to research, a disruption in the intestinal microbiota causes a decrease in short-chain fatty acids (SCFAs), alters the metabolism of bile acids (BAs), branched-chain amino acids (BCAAs), lipopolysaccharide (LPS), and endotoxin secretion, resulting in insulin resistance, chronic inflammation, and the progression to type 2 diabetes mellitus (T2DM). Astragali Radix is a medicinal herb of the same genus as food that has been extensively researched for treating diabetes mellitus with promising results in recent years. Polysaccharides, saponins, flavonoids, and other components are important. Among them, Astragaloside has a role in protecting the cellular integrity of the pancreas and liver, can leading to alleviation of insulin resistance and reducing blood glucose and triglyceride (TC) levels; The primary impact of Astragalus polysaccharides (APS) on diabetes is a decrease in insulin resistance, encouragement of islet cell proliferation, and suppression of islet β cell death; Astragali Radix flavonoids are known to enhance immunity, anti-inflammatory, regulate glucose metabolism and control the progression of diabetes. This study summarizes recent studies on Astragali Radix and its group formulations in the treatment of type 2 diabetes mellitus by modulating the intestinal microbiota. Frontiers Media S.A. 2023-08-10 /pmc/articles/PMC10450032/ /pubmed/37638043 http://dx.doi.org/10.3389/fimmu.2023.1243834 Text en Copyright © 2023 Su, Tang, Tang, Long, Wang and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Su, Min
Tang, Ting
Tang, Weiwei
Long, Yu
Wang, Lin
Liu, Meiling
Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review
title Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review
title_full Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review
title_fullStr Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review
title_full_unstemmed Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review
title_short Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review
title_sort astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat t2dm: a research review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450032/
https://www.ncbi.nlm.nih.gov/pubmed/37638043
http://dx.doi.org/10.3389/fimmu.2023.1243834
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