hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC

BACKGROUND: Understanding how cancer signaling pathways promote an immunosuppressive program which sustains acquired or primary resistance to immune checkpoint blockade (ICB) is a crucial step in improving immunotherapy efficacy. Among the pathways that can affect ICB response is the interferon (IFN...

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Detalles Bibliográficos
Autores principales: Trono, Paola, Tocci, Annalisa, Palermo, Belinda, Di Carlo, Anna, D'Ambrosio, Lorenzo, D'Andrea, Daniel, Di Modugno, Francesca, De Nicola, Francesca, Goeman, Frauke, Corleone, Giacomo, Warren, Sarah, Paolini, Francesca, Panetta, Mariangela, Sperduti, Isabella, Baldari, Silvia, Visca, Paolo, Carpano, Silvia, Cappuzzo, Federico, Russo, Vincenzo, Tripodo, Claudio, Zucali, Paolo, Gregorc, Vanesa, Marchesi, Federica, Nistico, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450042/
https://www.ncbi.nlm.nih.gov/pubmed/37612043
http://dx.doi.org/10.1136/jitc-2023-006913

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