Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade

BACKGROUND: BANF1 is well known as a natural opponent of cyclic GMP-AMP synthase (cGAS) activity on genomic self-DNA. However, the roles of BANF1 in tumor immunity remain unclear. Here, we investigate the possible impact of BANF1 on antitumor immunity and response to immunotherapy. METHODS: The Canc...

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Detalles Bibliográficos
Autores principales: Wang, Minglei, Huang, Yiheng, Chen, Minxin, Wang, Weiyan, Wu, Fei, Zhong, Tao, Chen, Xiaozheng, Wang, Fei, Li, Yang, Yu, Jinming, Wu, Meng, Chen, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450060/
https://www.ncbi.nlm.nih.gov/pubmed/37620043
http://dx.doi.org/10.1136/jitc-2023-007035

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