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RIG-I recognizes metabolite-capped RNAs as signaling ligands

The innate immune receptor RIG-I recognizes 5′-triphosphate double-stranded RNAs (5′ PPP dsRNA) as pathogenic RNAs. Such RNA-ends are present in viral genomes and replication intermediates, and they activate the RIG-I signaling pathway to produce a potent interferon response essential for viral clea...

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Detalles Bibliográficos
Autores principales:	Schweibenz, Brandon D, Solotchi, Mihai, Hanpude, Pranita, Devarkar, Swapnil C, Patel, Smita S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450190/ https://www.ncbi.nlm.nih.gov/pubmed/37326006 http://dx.doi.org/10.1093/nar/gkad518

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