MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongation

The fidelity of alternative splicing (AS) patterns is essential for growth development and cell fate determination. However, the scope of the molecular switches that regulate AS remains largely unexplored. Here we show that MEN1 is a previously unknown splicing regulatory factor. MEN1 deletion resul...

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Detalles Bibliográficos
Autores principales: Jin, Bangming, Zhu, Jiamei, Pan, Ting, Yang, Yunqiao, Liang, Li, Zhou, Yuxia, Zhang, Tuo, Teng, Yin, Wang, Ziming, Wang, Xuyan, Tian, Qianting, Guo, Bing, Li, Haiyang, Chen, Tengxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450199/
https://www.ncbi.nlm.nih.gov/pubmed/37395406
http://dx.doi.org/10.1093/nar/gkad548

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